Abstract

The purpose of the Animal Core is to consolidate the breeding, genotyping, care, and feeding of CF mice and the creation of the Pseudomonas agar bead model in order to achieve cost savings and to maximize the utilization of these valuable resources. In addition, the Animal Core will coordinate animals experiments so that different labs can study the same animals, where possible, and will provide uniform instruction for personnel in individual labs in methods of blood drawing, euthanasia, necropsy, processing of tissues and handling of fragile animals.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Specialized Center (P50)
Project #
5P50HL060293-05
Application #
6656536
Study Section
Project Start
2002-09-01
Project End
2003-08-31
Budget Start
Budget End
Support Year
5
Fiscal Year
2002
Total Cost
$263,865
Indirect Cost

  Institution

Name
Case Western Reserve University
Department
Type
DUNS #
077758407
City
Cleveland
State
OH
Country
United States
Zip Code
44106

  Publications

van Heeckeren, Anna M; Schluchter, Mark D; Xue, Wei et al. (2006) Response to acute lung infection with mucoid Pseudomonas aeruginosa in cystic fibrosis mice. Am J Respir Crit Care Med 173:288-96
Waters, Valerie; Sokol, Sach; Reddy, Bharat et al. (2005) The effect of cyclosporin A on airway cell proinflammatory signaling and pneumonia. Am J Respir Cell Mol Biol 33:138-44
Kube, Dianne M; Fletcher, David; Davis, Pamela B (2005) Relation of exaggerated cytokine responses of CF airway epithelial cells to PAO1 adherence. Respir Res 6:69
Van Heeckeren, Anna M; Scaria, Abraham; Schluchter, Mark D et al. (2004) Delivery of CFTR by adenoviral vector to cystic fibrosis mouse lung in a model of chronic Pseudomonas aeruginosa lung infection. Am J Physiol Lung Cell Mol Physiol 286:L717-26
Muir, Amanda; Soong, Grace; Sokol, Sach et al. (2004) Toll-like receptors in normal and cystic fibrosis airway epithelial cells. Am J Respir Cell Mol Biol 30:777-83
Gupta, Sanhita; Xie, Junxia; Ma, Jianjie et al. (2004) Intermolecular interaction between R domains of cystic fibrosis transmembrane conductance regulator. Am J Respir Cell Mol Biol 30:242-8
Adamo, Robert; Sokol, Sach; Soong, Grace et al. (2004) Pseudomonas aeruginosa flagella activate airway epithelial cells through asialoGM1 and toll-like receptor 2 as well as toll-like receptor 5. Am J Respir Cell Mol Biol 30:627-34
van Heeckeren, Anna M; Schluchter, Mark; Xue, Lintong et al. (2004) Nutritional effects on host response to lung infections with mucoid Pseudomonas aeruginosa in mice. Infect Immun 72:1479-86
van Heeckeren, Anna M; Schluchter, Mark D; Drumm, Mitchell L et al. (2004) Role of Cftr genotype in the response to chronic Pseudomonas aeruginosa lung infection in mice. Am J Physiol Lung Cell Mol Physiol 287:L944-52
Ferkol, Thomas; Cohn, Leah A; Phillips, Thomas E et al. (2003) Targeted delivery of antiprotease to the epithelial surface of human tracheal xenografts. Am J Respir Crit Care Med 167:1374-9

Showing the most recent 10 out of 18 publications