Abstract

Each of the four projects in the SCOR will be supported by the Histology Core. The functions of the histology core will be to (1) perform in-depth analysis of mutant mouse phenotypes at the histological level, (2) characterize alterations in gene expressions in mutant mouse strains, using in situ hybridization and immunocytochemicals techniques (3) characterize alterations in gene expressions in mutant mouse strains, using in situ hybridization and immunocytochemicals techniques (3) analyze and interpret the expression patterns of lacZ transgene in wildtype and mutant mouse background. The histology core will be supervised by Dr. James Richardson at UT Southwestern.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Specialized Center (P50)
Project #
5P50HL061033-03
Application #
6451099
Study Section
Project Start
2001-01-01
Project End
2001-12-31
Budget Start
Budget End
Support Year
3
Fiscal Year
2001
Total Cost
$186,685
Indirect Cost

  Institution

Name
University of Texas Sw Medical Center Dallas
Department
Type
DUNS #
City
Dallas
State
TX
Country
United States
Zip Code
75390

  Publications

Hullinger, Thomas G; Montgomery, Rusty L; Seto, Anita G et al. (2012) Inhibition of miR-15 protects against cardiac ischemic injury. Circ Res 110:71-81
Song, Kunhua; Nam, Young-Jae; Luo, Xiang et al. (2012) Heart repair by reprogramming non-myocytes with cardiac transcription factors. Nature 485:599-604
Xin, Mei; Kim, Yuri; Sutherland, Lillian B et al. (2011) Regulation of insulin-like growth factor signaling by Yap governs cardiomyocyte proliferation and embryonic heart size. Sci Signal 4:ra70
Montgomery, Rusty L; Hullinger, Thomas G; Semus, Hillary M et al. (2011) Therapeutic inhibition of miR-208a improves cardiac function and survival during heart failure. Circulation 124:1537-47
O'Rourke, Jason R; Olson, Eric N (2011) Modulating the MicroRNArchitecture of an aging aorta. Circ Res 109:1098-9
Porrello, Enzo R; Olson, Eric N (2010) Building a new heart from old parts: stem cell turnover in the aging heart. Circ Res 107:1292-4
Kwon, Chulan; Qian, Li; Cheng, Paul et al. (2009) A regulatory pathway involving Notch1/beta-catenin/Isl1 determines cardiac progenitor cell fate. Nat Cell Biol 11:951-7
Barlow, Gillian M; Micales, Bruce; Chen, Xiao-Ning et al. (2002) Mammalian DSCAMs: roles in the development of the spinal cord, cortex, and cerebellum? Biochem Biophys Res Commun 293:881-91
Barlow, G M; Micales, B; Lyons, G E et al. (2001) Down syndrome cell adhesion molecule is conserved in mouse and highly expressed in the adult mouse brain. Cytogenet Cell Genet 94:155-62
Yamagishi, H; Yamagishi, C; Nakagawa, O et al. (2001) The combinatorial activities of Nkx2.5 and dHAND are essential for cardiac ventricle formation. Dev Biol 239:190-203

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