Abstract

This is a proposal for a Mental Health Clinical Research Center (MHCRC) to be located at the Maryland Psychiatric Research Center (MPRC), a facility almost exclusively dedicated to the study of schizophrenia. To date, investigations undertaken at the Maryland Psychiatric Research Center have, for the most part, been independent efforts, although intramural collaborative studies of limited scope have been carried out. The next major growth phase of the MPRC will involve the generation of a workable and meaningful collaborative psychiatric research program in schizophrenia. It is with such an overall plan in mind that the present MHCRC proposal was conceived. Linking seven major research components, the core support requested will provide the administrative and operational structure to allow the integration of heretofore diverse, relatively independent projects and will formulate objectives in terms of a unifying, central focus having major clinical import: the classification and course of the schizophrenias. Viewed in this respect, the proposed Center is not only consistent with the development of the MPRC as a fully dedicated research resource, but provides the necessary framework by which the integration of studies of schizophrenia can be accomplished.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Specialized Center (P50)
Project #
5P50MH040279-03
Application #
3107127
Study Section
(TDAC)
Project Start
1986-02-15
Project End
1990-06-30
Budget Start
1988-02-01
Budget End
1990-06-30
Support Year
3
Fiscal Year
1988
Total Cost
Indirect Cost

  Institution

Name
University of Maryland Baltimore
Department
Type
Schools of Medicine
DUNS #
003255213
City
Baltimore
State
MD
Country
United States
Zip Code
21201

  Publications

Kelly, Deanna L; McMahon, Robert P; Wehring, Heidi J et al. (2011) Cigarette smoking and mortality risk in people with schizophrenia. Schizophr Bull 37:832-8
Warren, Kimberly R; Ball, M Patricia; Feldman, Stephanie et al. (2011) Exercise program adherence using a 5-kilometer (5K) event as an achievable goal in people with schizophrenia. Biol Res Nurs 13:383-90
Wehring, Heidi J; Liu, Fang; McMahon, Robert P et al. (2010) The relationship of brain weight to body mass index (BMI) upon autopsy in young people with severe mental illness. Schizophr Res 123:86-7
Kelly, Deanna L; McMahon, Robert P; Liu, Fang et al. (2010) Cardiovascular disease mortality in patients with chronic schizophrenia treated with clozapine: a retrospective cohort study. J Clin Psychiatry 71:304-11
Kelly, D L; Weiner, E; Ball, M P et al. (2009) Remission in schizophrenia: the relationship to baseline symptoms and changes in symptom domains during a one-year study. J Psychopharmacol 23:436-41
Kelly, Deanna L; Wehring, Heidi J; Linthicum, Jared et al. (2009) Cardiac-related findings at autopsy in people with severe mental illness treated with clozapine or risperidone. Schizophr Res 107:134-8
McMahon, Robert P; Kelly, Deanna L; Boggs, Douglas L et al. (2008) Feasibility of reducing the duration of placebo-controlled trials in schizophrenia research. Schizophr Bull 34:292-301
Boggs, Douglas L; Kelly, Deanna L; Love, Raymond C et al. (2008) Comparison of clozapine response for inpatients in the research setting versus routine clinical practice. Psychiatr Q 79:111-9
Kelly, Deanna L; Conley, Robert R; Love, Raymond C et al. (2008) Metabolic risk with second-generation antipsychotic treatment: a double-blind randomized 8-week trial of risperidone and olanzapine. Ann Clin Psychiatry 20:71-8
Kelly, Deanna L; Kreyenbuhl, Julie; Dixon, Lisa et al. (2007) Clozapine underutilization and discontinuation in African Americans due to leucopenia. Schizophr Bull 33:1221-4

Showing the most recent 10 out of 21 publications