Core - Modeling

Herman, William H.

Abstract

(Taken directly from the application): The overall objective of this Core is to facilitate disease, cost, and quality of life modeling to assess the relative effectiveness, cost-effectiveness, and cost utility of alternative strategies for the prevention, detection, and management of NIDDM.
The aims of the Core are to provide two key services within the Demonstration and Education (D&E) Division. These include: 1. conduct cost-effectiveness analyses within projects by adapting existing models and apply them to new interventions to provide summary measures of cost-effectiveness; and 2. assist in the plan and development new projects to incorporate assessment of resource utilization, costs, and health utilities. The need for the Core is predicated on the fact that no single clinical trial or observational study will be able to address the relative effectiveness and cost-effectiveness of alternative strategies for the prevention and treatment of diabetes whereas the model will permit such assessments. The research base for the Core includes the three projects within the Outcomes Evaluations Core of the D&E Division. Other potential applications of the Modeling Core are in the areas of new therapies, clinical trials, and epidemiologic studies. The areas of expertise brought together by the Core are epidemiology, biostatistics, health economics, psychometrics, and health services research.

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
• Type: Comprehensive Center (P60)
• Project #: 3P60DK020572-25S1
• Application #: 6666353
• Project Start: 2001-12-01
• Project End: 2002-11-30
• Support Year: 25
• Fiscal Year: 2002

Institution

• Name: University of Michigan Ann Arbor
• DUNS #: 791277940
• City: Ann Arbor
• State: MI
• Country: United States
• Zip Code: 48109

Publications

Zhao, Xu-Yun; Xiong, Xuelian; Liu, Tongyu et al. (2018) Long noncoding RNA licensing of obesity-linked hepatic lipogenesis and NAFLD pathogenesis. Nat Commun 9:2986

Dreffs, Alyssa; Henderson, Desmond; Dmitriev, Andrey V et al. (2018) Retinal pH and Acid Regulation During Metabolic Acidosis. Curr Eye Res 43:902-912

Kumar, Navasuja; Pop-Busui, Rodica; Musch, David C et al. (2018) Central Corneal Thickness Increase Due to Stromal Thickening With Diabetic Peripheral Neuropathy Severity. Cornea 37:1138-1142

Wilson, Matthew J; Sen, Ananda; Bridges, Dave et al. (2018) Higher baseline expression of the PTGS2 gene and greater decreases in total colonic fatty acid content predict greater decreases in colonic prostaglandin-E2 concentrations after dietary supplementation with ?-3 fatty acids. Prostaglandins Leukot Essent Fatty Acids 139:14-19

Sucularli, Ceren; Thomas, Peedikayil; Kocak, Hande et al. (2018) High-throughput gene expression analysis identifies p53-dependent and -independent pathways contributing to the adrenocortical dysplasia (acd) phenotype. Gene 679:219-231

Kady, Nermin M; Liu, Xuwen; Lydic, Todd A et al. (2018) ELOVL4-Mediated Production of Very Long-Chain Ceramides Stabilizes Tight Junctions and Prevents Diabetes-Induced Retinal Vascular Permeability. Diabetes 67:769-781

Malik, Ahmed M; Miguez, Roberto A; Li, Xingli et al. (2018) Matrin 3-dependent neurotoxicity is modified by nucleic acid binding and nucleocytoplasmic localization. Elife 7:

Lee, Pearl G; Ha, Jinkyung; Blaum, Caroline S et al. (2018) Patterns of physical activity in sedentary older individuals with type 2 diabetes. Clin Diabetes Endocrinol 4:7

Ramos, Carla J; Lin, Chengmao; Liu, Xuwen et al. (2018) The EPAC-Rap1 pathway prevents and reverses cytokine-induced retinal vascular permeability. J Biol Chem 293:717-730

Djuric, Zora; Bassis, Christine M; Plegue, Melissa A et al. (2018) Colonic Mucosal Bacteria Are Associated with Inter-Individual Variability in Serum Carotenoid Concentrations. J Acad Nutr Diet 118:606-616.e3