The Diabetes Research and Training Center (DRTC) at Vanderbilt is one of a network of Core Centers established by the National Institute of Diabetes, Digestive and Kidney Diseases (NIDDK) to conduct research and training in diabetes mellitus and related endocrine and metabolic disorders consistent with the National Diabetes Mellitus Research and Education Act, the report of the National Commission on Diabetes, and the Administrative Guidelines for DRTCs, as promulgated by the NIDDK. The Vanderbilt DRTC is a multi-disciplinary program with 111 participating faculty and staff members distributed among 13 departments in 2 schools and 3 colleges of the University. The Biomedical Research Component consists of a research base of 81 investigators in the following interest areas: Etiology, Gene Regulation/Function, Beta Cell Function/Channel Biology, Complications, Nutrition/Obesity, Metabolic Regulation, Signal Transduction These investigators are supported by seven Biomedical Research core facilities including Hormone Assay, Amino Acid Assay, Cell Imaging, Transgenic Mouse/ES Cell, Animal Resources, DNA Microarray and DNA Sequencing. Research formerly supported by a Model Demonstration Unit-Education/Evaluation component of the DRTC is now supported by an independently acquired research base in the Prevention/Control and Clinical Component. A major focus of this research is the disparity in diabetes care in underserved populations. This research, by 7 investigators, is supported by a Clinical Outcomes and Behavioral Sciences core. Four faculty members from Meharry Medical College also participate in this aspect of the DRTC through a Meharry Behavioral Health Disparities Core subcontract. A Pilot and Feasibility Studies Program provides up to two years of support in an effort to help new investigators initiate their research programs in diabetes or a related area. Established investigators who wish to enter the field of diabetes are also eligible. The Center coordinates three NIH/NIDDK-sponsored training programs that provide education and laboratory training in diabetes /endocrinology to medical students and graduate students and postdoctoral training for MDs and PhDs. An Enrichment Program provides continuing education through a Diabetes Research Day, a seminar series and symposia. The Administrative Component provides both scientific and administrative leadership for the total program.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Comprehensive Center (P60)
Project #
5P60DK020593-27
Application #
6874921
Study Section
Special Emphasis Panel (ZDK1-GRB-D (J2))
Program Officer
Abraham, Kristin M
Project Start
1996-02-13
Project End
2007-03-31
Budget Start
2005-04-01
Budget End
2006-03-31
Support Year
27
Fiscal Year
2005
Total Cost
$2,167,530
Indirect Cost
Name
Vanderbilt University Medical Center
Department
Physiology
Type
Schools of Medicine
DUNS #
004413456
City
Nashville
State
TN
Country
United States
Zip Code
37212
Lockhart, Jacob N; Spoonmore, Thomas J; McCurdy, Michael W et al. (2018) Poly(glycidol) Coating on Ultrahigh Molecular Weight Polyethylene for Reduced Biofilm Growth. ACS Appl Mater Interfaces 10:4050-4056
Shropshire, J Dylan; On, Jungmin; Layton, Emily M et al. (2018) One prophage WO gene rescues cytoplasmic incompatibility in Drosophila melanogaster. Proc Natl Acad Sci U S A 115:4987-4991
Sucre, Jennifer M S; Deutsch, Gail H; Jetter, Christopher S et al. (2018) A Shared Pattern of ?-Catenin Activation in Bronchopulmonary Dysplasia and Idiopathic Pulmonary Fibrosis. Am J Pathol 188:853-862
Schlegel, Cameron; Weis, Victoria G; Knowles, Byron C et al. (2018) Apical Membrane Alterations in Non-intestinal Organs in Microvillus Inclusion Disease. Dig Dis Sci 63:356-365
Wilson, Christopher S; Chhabra, Preeti; Marshall, Andrew F et al. (2018) Healthy Donor Polyclonal IgMs Diminish B-Lymphocyte Autoreactivity, Enhance Regulatory T-Cell Generation, and Reverse Type 1 Diabetes in NOD Mice. Diabetes 67:2349-2360
Hughey, Curtis C; Trefts, Elijah; Bracy, Deanna P et al. (2018) Glycine N-methyltransferase deletion in mice diverts carbon flux from gluconeogenesis to pathways that utilize excess methionine cycle intermediates. J Biol Chem 293:11944-11954
Yao, Lina; Seaton, Sarah Craven; Ndousse-Fetter, Sula et al. (2018) A selective gut bacterial bile salt hydrolase alters host metabolism. Elife 7:
Mani, Bharath K; Castorena, Carlos M; Osborne-Lawrence, Sherri et al. (2018) Ghrelin mediates exercise endurance and the feeding response post-exercise. Mol Metab 9:114-130
Bolus, W Reid; Peterson, Kristin R; Hubler, Merla J et al. (2018) Elevating adipose eosinophils in obese mice to physiologically normal levels does not rescue metabolic impairments. Mol Metab 8:86-95
West, Kathryn L; Kelm, Nathaniel D; Carson, Robert P et al. (2018) Myelin volume fraction imaging with MRI. Neuroimage 182:511-521

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