Abstract

The research proposed for this award will examine how spatial attention modulates cortical circuit activity in the eariy visual system. The proposed studies link the candidate's scientific bacl

Public Health Relevance

Understanding the function of cortical circuits in the brain has Important implications for understanding, treating, and educating people with conditions of debilitating brain disorganization. Elucidating the mechanisms of visual attention at cellular and circuit levels will advance knowledge of human cognition allowing for improvements in disease prevention and treatment and in the quality of human life.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Research Transition Award (R00)
Project #
5R00EY018683-04
Application #
8267025
Study Section
Special Emphasis Panel (NSS)
Program Officer
Steinmetz, Michael A
Project Start
2011-06-01
Project End
2014-05-31
Budget Start
2012-06-01
Budget End
2013-05-31
Support Year
4
Fiscal Year
2012
Total Cost
$226,335
Indirect Cost
$3,988

  Institution

Name
Dartmouth College
Department
Physiology
Type
Schools of Medicine
DUNS #
041027822
City
Hanover
State
NH
Country
United States
Zip Code
03755

  Publications

Hasse, J Michael; Bragg, Elise M; Murphy, Allison J et al. (2018) Morphological heterogeneity among corticogeniculate neurons in ferrets: quantification and comparison with a previous report in macaque monkeys. J Comp Neurol :
Bragg, Elise M; Fairless, Elizabeth A; Liu, Shiyuan et al. (2017) Morphology of visual sector thalamic reticular neurons in the macaque monkey suggests retinotopically specialized, parallel stream-mixed input to the lateral geniculate nucleus. J Comp Neurol 525:1273-1290
Hasse, J Michael; Briggs, Farran (2017) Corticogeniculate feedback sharpens the temporal precision and spatial resolution of visual signals in the ferret. Proc Natl Acad Sci U S A 114:E6222-E6230
Hembrook-Short, Jacqueline R; Mock, Vanessa L; Briggs, Farran (2017) Attentional Modulation of Neuronal Activity Depends on Neuronal Feature Selectivity. Curr Biol 27:1878-1887.e5
Bragg, Elise M; Briggs, Farran (2017) Large-scale Reconstructions and Independent, Unbiased Clustering Based on Morphological Metrics to Classify Neurons in Selective Populations. J Vis Exp :
Briggs, Farran; Kiley, Caitlin W; Callaway, Edward M et al. (2016) Morphological Substrates for Parallel Streams of Corticogeniculate Feedback Originating in Both V1 and V2 of the Macaque Monkey. Neuron 90:388-99
Briggs, Farran; Mangun, George R; Usrey, W Martin (2013) Attention enhances synaptic efficacy and the signal-to-noise ratio in neural circuits. Nature 499:476-80
Briggs, Farran; Usrey, W Martin (2011) Distinct mechanisms for size tuning in primate visual cortex. J Neurosci 31:12644-9
Briggs, Farran; Usrey, W Martin (2011) Corticogeniculate feedback and visual processing in the primate. J Physiol 589:33-40