Abstract

G-Prolein Coupled Receptors (GPCRs) comprise a relatively large portion of the human genome (-5% of all transcripts in the genome), and signaling between GPCRs, small G proteins, and various downstream effectors is controlled by Regulator of G-protein Signaling

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Transition Award (R00)
Project #
4R00HL087513-03
Application #
7760735
Study Section
Special Emphasis Panel (NSS)
Program Officer
Gao, Yunling
Project Start
2009-02-23
Project End
2012-01-31
Budget Start
2009-02-23
Budget End
2010-01-31
Support Year
3
Fiscal Year
2009
Total Cost
$249,000
Indirect Cost

  Institution

Name
University of Washington
Department
Pathology
Type
Schools of Medicine
DUNS #
605799469
City
Seattle
State
WA
Country
United States
Zip Code
98195

  Publications

Bahrami, Arya J; Gunaje, Jagadambika J; Hayes, Brian J et al. (2014) Regulator of G-protein signaling-5 is a marker of hepatic stellate cells and expression mediates response to liver injury. PLoS One 9:e108505
Weyers, Jill J; Schwartz, Stephen M; Minami, Elina et al. (2013) Effects of cell grafting on coronary remodeling after myocardial infarction. J Am Heart Assoc 2:e000202
Ieronimakis, Nicholas; Hays, Aislinn L; Janebodin, Kajohnkiart et al. (2013) Coronary adventitial cells are linked to perivascular cardiac fibrosis via TGF?1 signaling in the mdx mouse model of Duchenne muscular dystrophy. J Mol Cell Cardiol 63:122-34
Mahoney Jr, William M; Gunaje, Jagadambika; Daum, Guenter et al. (2013) Regulator of G-protein signaling - 5 (RGS5) is a novel repressor of hedgehog signaling. PLoS One 8:e61421
Majesky, Mark W; Dong, Xiu Rong; Hoglund, Virginia et al. (2012) The adventitia: a progenitor cell niche for the vessel wall. Cells Tissues Organs 195:73-81
Weyers, Jill J; Carlson, Dara D; Murry, Charles E et al. (2012) Retrograde perfusion and filling of mouse coronary vasculature as preparation for micro computed tomography imaging. J Vis Exp :e3740
Gunaje, Jagadambika J; Bahrami, Arya J; Schwartz, Stephen M et al. (2011) PDGF-dependent regulation of regulator of G protein signaling-5 expression and vascular smooth muscle cell functionality. Am J Physiol Cell Physiol 301:C478-89
Majesky, Mark W; Dong, Xiu Rong; Hoglund, Virginia et al. (2011) The adventitia: a dynamic interface containing resident progenitor cells. Arterioscler Thromb Vasc Biol 31:1530-9