Abstract

A program of studies will examine the action of ethanol on motor performance. Rats will be used as experimental models to examine basic principles of sensory and motor integration. One concept to be explored is that ethanol disrupts sensor1-motor integration by impairing the capacity of motor centers to regulate or """"""""gate"""""""" sensory transmission. Acute and chronic doses of ethanol will be administered. Experimental observation will be made of: video based recordings of steady locomotor and random movements, footfall events detected electronically on a treadmill, and single unit recordings in sensory and motor cerebral cortex, cerebellum and striatum. Iontophoresis of putative transmitters in awake animals will be done to examine actions of ethanol on components of synaptic systems. The uptake of 14C-2deoxyglucose will be assayed by computer based analysis of autoradiographs. Regional brain variations will be imaged under conditions of acute and chronic ethanol administration. These studies will characterize regional and global changes in brain actively which may be the basis for actions of ethanol on """"""""attentional"""""""" mechanisms and other processes which regulate motor performance.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Type
Research Project (R01)
Project #
2R01AA003901-07
Application #
3108859
Study Section
Alcohol Biomedical Research Review Committee (ALCB)
Project Start
1978-12-01
Project End
1989-02-28
Budget Start
1985-03-01
Budget End
1986-02-28
Support Year
7
Fiscal Year
1985
Total Cost
Indirect Cost

  Institution

Name
University of Texas Sw Medical Center Dallas
Department
Type
Overall Medical
DUNS #
City
Dallas
State
TX
Country
United States
Zip Code
75390

  Publications

Lee, R S; Smith, S S; Chapin, J K et al. (1995) Effects of systemic and local ethanol on responses of rat cerebellar Purkinje neurons to iontophoretically applied gamma-aminobutyric acid. Brain Res 687:1-11
Chang, J Y; Sawyer, S F; Lee, R S et al. (1994) Electrophysiological and pharmacological evidence for the role of the nucleus accumbens in cocaine self-administration in freely moving rats. J Neurosci 14:1224-44
Woodward, D J; Moises, H C; Waterhouse, B D et al. (1991) The cerebellar norepinephrine system: inhibition, modulation, and gating. Prog Brain Res 88:331-41
Smith, W K; Woodward, D J (1990) A data exchange format for neuroanatomy workstations. Comput Med Imaging Graph 14:371-7
Crockett, D P; Smith, W K; Proshansky, E et al. (1989) Computer-assisted three-dimensional reconstructions of [14C]-2-deoxy-D-glucose metabolism in cat lumbosacral spinal cord following cutaneous stimulation of the hindfoot. J Comp Neurol 288:326-38
Smith, S S; Waterhouse, B D; Woodward, D J (1988) Locally applied estrogens potentiate glutamate-evoked excitation of cerebellar Purkinje cells. Brain Res 475:272-82
Smith, S S; Waterhouse, B D; Chapin, J K et al. (1987) Progesterone alters GABA and glutamate responsiveness: a possible mechanism for its anxiolytic action. Brain Res 400:353-9
Smith, S S; Waterhouse, B D; Woodward, D J (1987) Sex steroid effects on extrahypothalamic CNS. I. Estrogen augments neuronal responsiveness to iontophoretically applied glutamate in the cerebellum. Brain Res 422:40-51
Azizi, S A; Woodward, D J (1987) Inferior olivary nuclear complex of the rat: morphology and comments on the principles of organization within the olivocerebellar system. J Comp Neurol 263:467-84
Smith, S S; Waterhouse, B D; Woodward, D J (1987) Sex steroid effects on extrahypothalamic CNS. II. Progesterone, alone and in combination with estrogen, modulates cerebellar responses to amino acid neurotransmitters. Brain Res 422:52-62

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