Abstract

This investigation addresses the need to define the neural circuit mechanisms by which ethanol disrupts higher-order selective sensory processing in primary and associative areas of the cerebral cortex. As neurophysiological models for such processing, the PI has described several types of sensory modulation in the somatosensory cortex of rats. These include: 1) inhibitory sensory """"""""gating"""""""" occurring in phase with forelimb movement, 2) sensory facilitation occurring in arousal, and 3) sensory facilitation occurring in attention and anticipation behaviors. All these phenomena will be investigated using a technique the PI has developed for simultaneous recording from multiple single neurons through arrays of microwire electrodes chronically implanted in precise locations the cortex and thalamus. The major aim will be to test the effects of ethanol on normal circuit interactions exhibited in these recordings. Also, the long term stability of such recordings will allow the same neurons to be recorded over the time course of ethanol chronicity and withdrawal, and over administrations of other drugs of abuse. Finally, genetic models (such as P-NP rats) will be used.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Type
Research Project (R01)
Project #
5R01AA006965-06
Application #
3110435
Study Section
Biochemistry, Physiology and Medicine Subcommittee (ALCB)
Project Start
1987-04-01
Project End
1993-03-31
Budget Start
1991-04-01
Budget End
1992-03-31
Support Year
6
Fiscal Year
1991
Total Cost
Indirect Cost

  Institution

Name
Allegheny University of Health Sciences
Department
Type
Schools of Medicine
DUNS #
City
Philadelphia
State
PA
Country
United States
Zip Code
19129

  Publications

Nicolelis, M A; Chapin, J K (1994) Spatiotemporal structure of somatosensory responses of many-neuron ensembles in the rat ventral posterior medial nucleus of the thalamus. J Neurosci 14:3511-32
Shin, H C; Park, H J; Chapin, J K (1994) Differential phasic modulation of short and long latency afferent sensory transmission to single neurons in the primary somatosensory cortex in behaving rats. Neurosci Res 19:419-25
Kosobud, A E; Harris, G C; Chapin, J K (1994) Behavioral associations of neuronal activity in the ventral tegmental area of the rat. J Neurosci 14:7117-29
Nicolelis, M A; Lin, R C; Woodward, D J et al. (1993) Dynamic and distributed properties of many-neuron ensembles in the ventral posterior medial thalamus of awake rats. Proc Natl Acad Sci U S A 90:2212-6
Shin, H C; Park, H J; Chapin, J K (1993) Differential phasic modulation of short and long latency afferent sensory transmission to single neurons in the ventroposterolateral thalamus in behaving rats. Neurosci Res 17:117-25
Nicolelis, M A; Chapin, J K; Lin, R C (1991) Neonatal whisker removal in rats stabilizes a transient projection from the auditory thalamus to the primary somatosensory cortex. Brain Res 567:133-9
Nicolelis, M A; Chapin, J K; Lin, C S (1991) Ontogeny of corticocortical projections of the rat somatosensory cortex. Somatosens Mot Res 8:193-200
Patel, I M; Chapin, J K (1990) Ketamine effects on somatosensory cortical single neurons and on behavior in rats. Anesth Analg 70:635-44
Shin, H C; Chapin, J K (1990) Movement induced modulation of afferent transmission to single neurons in the ventroposterior thalamus and somatosensory cortex in rat. Exp Brain Res 81:515-22
Lin, C S; Nicolelis, M A; Schneider, J S et al. (1990) A major direct GABAergic pathway from zona incerta to neocortex. Science 248:1553-6

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