Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Type
Research Project (R01)
Project #
5R01AA007818-06
Application #
2044154
Study Section
Biochemistry, Physiology and Medicine Subcommittee (ALCB)
Project Start
1989-04-01
Project End
1998-05-31
Budget Start
1996-06-01
Budget End
1997-05-31
Support Year
6
Fiscal Year
1996
Total Cost
Indirect Cost

  Institution

Name
University of Nebraska Medical Center
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
City
Omaha
State
NE
Country
United States
Zip Code
68198

  Publications

Thiele, Geoffrey M; Klassen, Lynell W; Tuma, Dean J (2008) Formation and immunological properties of aldehyde-derived protein adducts following alcohol consumption. Methods Mol Biol 447:235-57
Duryee, Michael J; Freeman, Thomas L; Willis, Monte S et al. (2005) Scavenger receptors on sinusoidal liver endothelial cells are involved in the uptake of aldehyde-modified proteins. Mol Pharmacol 68:1423-30
Duryee, Michael J; Klassen, Lynell W; Freeman, Thomas L et al. (2004) Lipopolysaccharide is a cofactor for malondialdehyde-acetaldehyde adduct-mediated cytokine/chemokine release by rat sinusoidal liver endothelial and Kupffer cells. Alcohol Clin Exp Res 28:1931-8
Duryee, Michael J; Willis, Monte S; Freeman, Thomas L et al. (2004) Mechanisms of alcohol liver damage: aldehydes, scavenger receptors, and autoimmunity. Front Biosci 9:3145-55
Willis, Monte S; Klassen, Lynell W; Carlson, Deborah L et al. (2004) Malondialdehyde-acetaldehyde haptenated protein binds macrophage scavenger receptor(s) and induces lysosomal damage. Int Immunopharmacol 4:885-99
Willis, Monte S; Thiele, Geoffrey M; Tuma, Dean J et al. (2003) T cell proliferative responses to malondialdehyde-acetaldehyde haptenated protein are scavenger receptor mediated. Int Immunopharmacol 3:1381-99
Duryee, Michael J; Klassen, Lynell W; Freeman, Thomas L et al. (2003) Chronic ethanol consumption impairs receptor-mediated endocytosis of MAA-modified albumin by liver endothelial cells. Biochem Pharmacol 66:1045-54
Thiele, Geoffrey M; Szabo, Gyongyi; Kovacs, Elizabeth J et al. (2002) Modulation of immunity and viral-host interactions by alcohol. Alcohol Clin Exp Res 26:1897-908
Willis, Monte S; Klassen, Lynell W; Tuma, Dean J et al. (2002) In vitro exposure to malondialdehyde-acetaldehyde adducted protein inhibits cell proliferation and viability. Alcohol Clin Exp Res 26:158-64
Willis, Monte S; Klassen, Lynell W; Tuma, Dean J et al. (2002) Adduction of soluble proteins with malondialdehyde-acetaldehyde (MAA) induces antibody production and enhances T-cell proliferation. Alcohol Clin Exp Res 26:94-106

Showing the most recent 10 out of 24 publications