This re-revised five-year proposal seeks funding for a twin-family study of adolescent alcohol use and abuse, and related behavioral risk-factors, using a prospective cohort-sequential design. Cohorts of female like-sex pairs, including minority twin pairs, who will be aged 13, 15, 17, and 19 by the time they are first studied, have been ascertained from state birth records (N=2350 twin pairs). Current addresses for the families will be traced, and zygosity information obtained by abbreviated telephone interview or mailed questionnaire (N= 1785 pairs). Over a four-year period, telephone screening interviews will be conducted with parents of the twins (N = 1500 families) and with twin pairs aged 17 and older (N=8O0 pairs). Approximately 310 pairs and their parent(s) will be randomly assigned for in-person interview, and a finder 190 'high-risk' families will be assigned for interview on the basis of parental or twin history of alcohol abuse or dependence. Annual abbreviated follow-up telephone interviews will be conducted with all available twin pairs at ages 16-22, and with the parents of twins aged 15; and biannual in-person follow-up interviews of the parents and twins from the 'high-risk' and random control families will also be conducted. We will assess in both the twins and their parents multiple measures of alcohol use (quantity/frequency/ abstinence, frequency of drinking to intoxication, maximum consumption, drinking-related psychosocial and other problems, abuse, dependence); associated behavioral and psychiatric risk-factors (conduct problems, conduct disorder, oppositionaI disorder, ADHD, depression, anxiety disorders, history of other drug use, academic failure); and postulated mediating and/or moderating variables (positive and negative alcohol expectancies; values; measures of temperament and personality; family environment; perceived environment). Methods of multivariate genetic analysis will be used to test hypotheses concerning the developmental pathways by which genetic risk for alcoholism and environmental risk- factors operate; to identify critical mediating and moderator variables in these developmental pathways; and to explore the joint and correlated action ('genotype-environment correlation') and interaction ('genotype x environment interaction') of genetic and environmental risk-factors. The project will thus address a critical gap in our knowledge of the etiology of adolescent drinking behavior.

Agency
National Institute of Health (NIH)
Institute
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Type
Research Project (R01)
Project #
5R01AA009022-02
Application #
2045059
Study Section
Clinical and Treatment Subcommittee (ALCP)
Project Start
1994-03-01
Project End
1998-11-30
Budget Start
1995-03-01
Budget End
1995-11-30
Support Year
2
Fiscal Year
1995
Total Cost
Indirect Cost
Name
Washington University
Department
Psychiatry
Type
Schools of Medicine
DUNS #
062761671
City
Saint Louis
State
MO
Country
United States
Zip Code
63130
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