Agency
National Institute of Health (NIH)
Institute
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Type
Research Project (R01)
Project #
5R01AA010039-02
Application #
2046477
Study Section
Special Emphasis Panel (SRCA (52))
Project Start
1995-02-01
Project End
2000-01-31
Budget Start
1996-02-01
Budget End
1997-01-31
Support Year
2
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Ernest Gallo Clinic and Research Center
Department
Type
DUNS #
173995366
City
Emeryville
State
CA
Country
United States
Zip Code
94608
Yao, Lina; Fan, Peidong; Jiang, Zhan et al. (2003) Addicting drugs utilize a synergistic molecular mechanism in common requiring adenosine and Gi-beta gamma dimers. Proc Natl Acad Sci U S A 100:14379-84
Yao, Lina; Arolfo, Maria Pia; Dohrman, Douglas P et al. (2002) betagamma Dimers mediate synergy of dopamine D2 and adenosine A2 receptor-stimulated PKA signaling and regulate ethanol consumption. Cell 109:733-43
Dohrman, Douglas P; Chen, Hui-min; Gordon, Adrienne S et al. (2002) Ethanol-induced translocation of protein kinase A occurs in two phases: control by different molecular mechanisms. Alcohol Clin Exp Res 26:407-15
Gordon, A S; Yao, L; Jiang, Z et al. (2001) Ethanol acts synergistically with a D2 dopamine agonist to cause translocation of protein kinase C. Mol Pharmacol 59:153-60
Yao, L; Asai, K; Jiang, Z et al. (2001) Dopamine D2 receptor inhibition of adenylyl cyclase is abolished by acute ethanol but restored after chronic ethanol exposure (tolerance). J Pharmacol Exp Ther 298:833-9
Constantinescu, A; Diamond, I; Gordon, A S (1999) Ethanol-induced translocation of cAMP-dependent protein kinase to the nucleus. Mechanism and functional consequences. J Biol Chem 274:26985-91
Ron, D; Jiang, Z; Yao, L et al. (1999) Coordinated movement of RACK1 with activated betaIIPKC. J Biol Chem 274:27039-46
Gordon, A S; Yao, L; Dohrman, D P et al. (1998) Ethanol alters the subcellular localization of cAMP-dependent protein kinase and protein kinase C. Alcohol Clin Exp Res 22:238S-242S
Gordon, A S; Yao, L; Wu, Z L et al. (1997) Ethanol alters the subcellular localization of delta- and epsilon protein kinase C in NG108-15 cells. Mol Pharmacol 52:554-9