This application requests four years of support to investigate the biobehavioral mechanisms mediating risk for alcohol abuse in human and non-human animal subjects.
The first aim of the project is to investigate the biobehavioral mechanisms hypothesized to mediate the relationship between disinhibited behavior and alcohol abuse. The central hypotheses are that a common vulnerability mediates the relationship between impulsive personality, disinhibited/antisocial behavior and alcohol abuse. The relationship between alcohol problems, disinhibited behavior, and individual differences in the strength of the Behavioral Inhibition and Activation Systems (i.e. the biobehavioral mechanisms), assessed using classical and instrumental conditioning of psychophysiological and motor responses, measures of autonomic arousal while awaiting an aversive event, and fear-potentiated startle will be examined using latent variable and structural-equation techniques in a sample of young men and women.
The second aim i s to investigate behavioral inhibition and activation functioning in replicated strains of rats bred for alcohol preference, alcohol preferring (P) rat and the high-alcohol drinking (HAD) rat, using conditioning protocols that parallel the human protocols, and to compare a human model of alcoholism-risk (persons with undercontrolled, disinhibited or aggressive behavior) with the animal model (the P and HAD rat) to determine how well the animal model generalizes to the human model in terms of behavioral inhibition and activation. In addition the predictive power of behavioral inhibition and activation function on alcohol consumption will be examined in a F-2 generation of cross bred P rats and alcohol non-preferring (NP) rats and HAD and low-alcohol drinking (LAD) rats. The results of this project should yield data relevant to the prevention of alcohol abuse, especially in high-risk youth. In addition, the results may inform treatment efforts with populations where antisocial personality is co-morbid with alcohol dependence.

Agency
National Institute of Health (NIH)
Institute
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Type
Research Project (R01)
Project #
1R01AA010120-01A1
Application #
2046607
Study Section
Biochemistry, Physiology and Medicine Subcommittee (ALCB)
Project Start
1995-04-01
Project End
1999-03-31
Budget Start
1995-04-01
Budget End
1996-03-31
Support Year
1
Fiscal Year
1995
Total Cost
Indirect Cost
Name
Indiana University Bloomington
Department
Psychology
Type
Schools of Arts and Sciences
DUNS #
006046700
City
Bloomington
State
IN
Country
United States
Zip Code
47401
Bogg, Tim; Finn, Peter R (2010) A self-regulatory model of behavioral disinhibition in late adolescence: integrating personality traits, externalizing psychopathology, and cognitive capacity. J Pers 78:441-70
Finn, Peter R; Hall, Julie (2004) Cognitive ability and risk for alcoholism: short-term memory capacity and intelligence moderate personality risk for alcohol problems. J Abnorm Psychol 113:569-81
Finn, Peter R (2002) Motivation, working memory, and decision making: a cognitive-motivational theory of personality vulnerability to alcoholism. Behav Cogn Neurosci Rev 1:183-205
Finn, Peter R; Mazas, Carlos A; Justus, Alicia N et al. (2002) Early-onset alcoholism with conduct disorder: go/no go learning deficits, working memory capacity, and personality. Alcohol Clin Exp Res 26:186-206
Justus, A N; Finn, P R; Steinmetz, J E (2001) P300, disinhibited personality, and early-onset alcohol problems. Alcohol Clin Exp Res 25:1457-66
Vogel-Sprott, M; Easdon, C; Fillmore, M et al. (2001) Alcohol and behavioral control: cognitive and neural mechanisms. Alcohol Clin Exp Res 25:117-21
Finn, P R; Justus, A N; Mazas, C et al. (2001) Constraint, alcoholism, and electrodermal response in aversive classical conditioning and mismatch novelty paradigms. Integr Physiol Behav Sci 36:154-67
Justus, A N; Finn, P R; Steinmetz, J E (2000) The influence of traits of disinhibition on the association between alcohol use and risky sexual behavior. Alcohol Clin Exp Res 24:1028-35
Blankenship, M R; Finn, P R; Steinmetz, J E (2000) A characterization of approach and avoidance learning in high-alcohol-drinking (HAD) and low-alcohol-drinking (LAD) rats. Alcohol Clin Exp Res 24:1778-84
Mazas, C A; Finn, P R; Steinmetz, J E (2000) Decision-making biases, antisocial personality, and early-onset alcoholism. Alcohol Clin Exp Res 24:1036-40

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