Abstract

A program of studies will be conducted to examine actions of ethanol on brain regions related to self-administration of ethanol and to sensory motor integration. Rats will be used as experimental models to study the activity of neurons which cause the behavioral task sequencing related to operant control of ethanol self-administration. The influence of sensory cues will be studied on the initiation maintenance and termination of a drinking 'bout'. Newly developed concurrent many-neuron recording techniques will be employed which utilize groups of chronically implanted microwires for neuron spike train detection and statistical/graphical analysis. Neuron recording will be conducted primarily in the mesolimbic system including the media prefrontal cortex subregions of the nucleus accumbens and the dopamine and nondopamine neurons of the ventral tegmental area. Neuron signals will be studied in relation to similar motor tasks leading to alternate rewards of ethanol or sucrose solution. Influence of ethanol on a tone cue reaction time task will be studied. This neurophysiological analysis of behavioral control will provide new insights into possible avenues for therapeutic regulation of ethanol consumption.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Type
Research Project (R01)
Project #
5R01AA010980-03
Application #
2683003
Study Section
Biochemistry, Physiology and Medicine Subcommittee (ALCB)
Project Start
1996-04-01
Project End
2001-03-31
Budget Start
1998-04-01
Budget End
1999-03-31
Support Year
3
Fiscal Year
1998
Total Cost
Indirect Cost

  Institution

Name
Wake Forest University Health Sciences
Department
Physiology
Type
Schools of Medicine
DUNS #
041418799
City
Winston-Salem
State
NC
Country
United States
Zip Code
27106

  Publications

Li, Xiang-Hong; Wang, Jin-Yan; Gao, Ge et al. (2010) High-frequency stimulation of the subthalamic nucleus restores neural and behavioral functions during reaction time task in a rat model of Parkinson's disease. J Neurosci Res 88:1510-21
Huang, Jin; Chang, Jing-Yu; Woodward, Donald J et al. (2006) Dynamic neuronal responses in cortical and thalamic areas during different phases of formalin test in rats. Exp Neurol 200:124-34
Yang, He; Chang, Jing-Yu; Woodward, Donald J et al. (2005) Coding of peripheral electrical stimulation frequency in thalamocortical pathways. Exp Neurol 196:138-52
Wang, Jin-Yan; Zhang, Han-Ti; Han, Ji-Sheng et al. (2004) Differential modulation of nociceptive neural responses in medial and lateral pain pathways by peripheral electrical stimulation: a multichannel recording study. Brain Res 1014:197-208
Anstrom, Kristin K; Cromwell, Howard C; Markowski, Tania et al. (2003) Effect of baclofen on alcohol and sucrose self-administration in rats. Alcohol Clin Exp Res 27:900-8
Wang, Jin-Yan; Luo, Fei; Chang, Jing-Yu et al. (2003) Parallel pain processing in freely moving rats revealed by distributed neuron recording. Brain Res 992:263-71
Chang, J-Y; Chen, L; Luo, F et al. (2002) Neuronal responses in the frontal cortico-basal ganglia system during delayed matching-to-sample task: ensemble recording in freely moving rats. Exp Brain Res 142:67-80
Woodward, D J; Chang, J Y; Janak, P et al. (2000) Activity patterns in mesolimbic regions in rats during operant tasks for reward. Prog Brain Res 126:303-22
Janak, P H; Chang, J Y; Woodward, D J (1999) Neuronal spike activity in the nucleus accumbens of behaving rats during ethanol self-administration. Brain Res 817:172-84
Woodward, D J; Chang, J Y; Janak, P et al. (1999) Mesolimbic neuronal activity across behavioral states. Ann N Y Acad Sci 877:91-112

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