Neurocognitive impairment is believed to affect alcoholism treatment process and outcome. However, alcohol researchers have had difficulty empirically validating this relationship between impairment and outcome, often finding weak and inconsistent support. This competitive renewal application seeks to extend a Rutgers CAS research program studying neurocognitive impairment in persons treated for alcohol use disorders. The unmet need to examine neurocognitive moderation models has often been highlighted by alcohol researchers and is strongly supported by the literature on the relation of neuropsychological impairment to behavioral outcomes following treatment for brain injuries of multiple etiologies. We have found support for a hypothesized model wherein neurocognitive impairment moderated the relation of robust change processes to intensity of alcohol and other drug use 6 months after treatment. Self-efficacy, commitment to abstinence, and AA affiliation were strong predictors of outcome in unimpaired persons, but only weak predictors of outcome in those who were impaired. Results supported a threshold model of impairment which suggests that only severe neurocognitive impairments may affect moderation. The goal of this competitive renewal application is to develop heuristic models of brain-behavior relations that adequately characterize the effect of alcohol-related neurocognitive impairment on treatment outcome through secondary analysis of three existing longitudinal data bases which overlap substantively in constructs and measures. We will use two convergent analytic methods to contrast direct effect, mediation, and moderation models of neurocognitive influences on alcohol- and drug-specific, and psychosocial outcomes within a conceptual framework informed by the traumatic brain injury rehabilitation literature. By examining the generality of results across different addictions treatment populations, we can provide a more robust test of putative neurocognitive models of treatment outcome than otherwise would be possible without costly collection of new longitudinal data. Results will advance understanding of mechanisms which support good outcomes in neurocognitively impaired individuals and will have theoretical implications for cognitive models of relapse.

Agency
National Institute of Health (NIH)
Institute
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Type
Research Project (R01)
Project #
5R01AA011594-06
Application #
6629617
Study Section
Health Services Research Review Subcommittee (AA)
Program Officer
Lowman, Cherry
Project Start
1997-09-01
Project End
2005-10-31
Budget Start
2003-05-01
Budget End
2005-10-31
Support Year
6
Fiscal Year
2003
Total Cost
$182,120
Indirect Cost
Name
Rutgers University
Department
Psychology
Type
Other Domestic Higher Education
DUNS #
001912864
City
New Brunswick
State
NJ
Country
United States
Zip Code
08901
Buckman, Jennifer F; Bates, Marsha E; Morgenstern, Jon (2008) Social support and cognitive impairment in clients receiving treatment for alcohol- and drug-use disorders: a replication study. J Stud Alcohol Drugs 69:738-46
Buckman, Jennifer F; Bates, Marsha E; Cisler, Ron A (2007) Social networks and their influence on drinking behaviors: differences related to cognitive impairment in clients receiving alcoholism treatment. J Stud Alcohol Drugs 68:738-47
Lashin, Ossama M; Szweda, Pamela A; Szweda, Luke I et al. (2006) Decreased complex II respiration and HNE-modified SDH subunit in diabetic heart. Free Radic Biol Med 40:886-96
Bates, Marsha E; Voelbel, Gerald T; Buckman, Jennifer F et al. (2005) Short-term neuropsychological recovery in clients with substance use disorders. Alcohol Clin Exp Res 29:367-77
Cefaratti, Christie; Young, Andrew; Romani, Andrea (2005) Effect of ethanol administration on Mg2+ transport across liver plasma membrane. Alcohol 36:5-18
Bates, Marsha E; Barry, Danielle; Labouvie, Erich W et al. (2004) Risk factors and neuropsychological recovery in clients with alcohol use disorders who were exposed to different treatments. J Consult Clin Psychol 72:1073-80
Bates, Marsha E; Lemay Jr, Edward P (2004) The d2 Test of attention: construct validity and extensions in scoring techniques. J Int Neuropsychol Soc 10:392-400
Lashin, Ossama; Romani, Andrea (2004) Hyperglycemia does not alter state 3 respiration in cardiac mitochondria from type-I diabetic rats. Mol Cell Biochem 267:31-7
Fals-Stewart, William; Bates, Marsha E (2003) The neuropsychological test performance of drug-abusing patients: an examination of latent cognitive abilities and associated risk factors. Exp Clin Psychopharmacol 11:34-45
Lashin, Ossama; Romani, Andrea (2003) Mitochondria respiration and susceptibility to ischemia-reperfusion injury in diabetic hearts. Arch Biochem Biophys 420:298-304

Showing the most recent 10 out of 16 publications