While the field of translational research is gaining increased attention, few teams have successfully integrated brain+behavioral approaches to examine the developing adolescent brain in the context of addiction treatment. PI Feldstein Ewing has been at the forefront of this work, highlighting that in contrast to adults who show reduced reward response in mesocorticolimbic regions during addiction treatment, adolescents' addiction behavior change revolves around enhanced default mode network response [DMN; precuneus, posterior cingulate gyrus (PCC), and middle frontal gyrus (MFG)]. Our foundational studies underscore in this age group, greater DMN response during critical elements of treatment (client language; therapist language) corresponds with greater behavior change (less problem drinking). Our foundational studies have also critically advanced neurodevelopmental addiction theory, illuminating 4 neuro-biobehavioral drivers of adolescent addiction treatment response, including innovative behavioral treatment approaches that planfully integrate a neurodevelopmental perspective and engage: (a) prosocial (vs. problem-based) approaches, (b) adolescents' drastically developing cognitive skills, (c) adolescents' developmentally-specific drive for autonomy, and (d) parents into programming. Following our team's established track record in adolescent intervention development, we aim to use the opportunity of this competitive continuation to maximize our formative translational (brain+behavioral) developmental neuroscience data and theory to inform the creation of a novel behavioral treatment for adolescent addiction (JUNO: Jumpstart Understanding of Neurodevelopmental Opportunity). This competitive continuation directly responds to NOT-AA-19-010's 2019 Notice Interest: of Special development and dissemination of behavioral treatments for alcohol use disorder.? Here,we propose to merge quantitative neurodevelopmental data from the 1st 4 years of this project with qualitative data from adolescent focus groups (Aim 1), to create a tailored for drinking neurodevelopmentally-responsive behavioral treatment youth (JUNO). We will then evaluate initial impact of this novel behavioral treatment on adolescent problem and proposed neurodevelopmental mechanisms (Aim 2).

Public Health Relevance

At this time, most American youth have consumed alcohol, with many engaging in binge drinking, one of the highest risk patterns of consumption; while existing interventions show promise, they do not work universally well for all youth. Thus,in this competitive continuation,we propose to merge quantitative neurodevelopmental data from the 1st 4 years of this project with qualitative data from adolescent focus groups, to create a tailored neurodevelopmentally-responsive this behavioral treatment for youth (JUNO). We will then evaluate initial impact of novel behavioral treatment on adolescent problem drinking and proposed neurodevelopmentalmechanisms.

Agency
National Institute of Health (NIH)
Institute
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Type
Research Project (R01)
Project #
7R01AA023658-06
Application #
10226461
Study Section
Special Emphasis Panel (ZAA1)
Program Officer
Kwako, Laura Elizabeth
Project Start
2020-09-20
Project End
2021-03-31
Budget Start
2020-09-20
Budget End
2021-03-31
Support Year
6
Fiscal Year
2019
Total Cost
Indirect Cost
Name
University of Rhode Island
Department
Psychology
Type
Sch Allied Health Professions
DUNS #
144017188
City
Kingston
State
RI
Country
United States
Zip Code
02881
Dash, Genevieve F; Wilson, Anna C; Morasco, Benjamin J et al. (2018) A Model of the Intersection of Pain and Opioid Misuse in Children and Adolescents. Clin Psychol Sci 6:629-646
Cousijn, Janna; Luijten, Maartje; Feldstein Ewing, Sarah W (2018) Adolescent resilience to addiction: a social plasticity hypothesis. Lancet Child Adolesc Health 2:69-78
Rømer Thomsen, Kristine; Blom Osterland, Tine; Hesse, Morten et al. (2018) The intersection between response inhibition and substance use among adolescents. Addict Behav 78:228-230
Rømer Thomsen, Kristine; Callesen, Mette Buhl; Feldstein Ewing, Sarah W (2017) Recommendation to reconsider examining cannabis subtypes together due to opposing effects on brain, cognition and behavior. Neurosci Biobehav Rev 80:156-158
Caouette, Justin D; Feldstein Ewing, Sarah W (2017) Four Mechanistic Models of Peer Influence on Adolescent Cannabis Use. Curr Addict Rep 4:90-99
Feldstein Ewing, Sarah W; Chung, Tammy; Caouette, Justin D et al. (2017) Orbitofrontal cortex connectivity as a mechanism of adolescent behavior change. Neuroimage 151:14-23
Feldstein Ewing, Sarah W; Lovejoy, Travis I; Choo, Esther K (2017) How Has Legal Recreational Cannabis Affected Adolescents in Your State? A Window of Opportunity. Am J Public Health 107:246-247
Feldstein Ewing, Sarah W; Apodaca, Timothy R; Gaume, Jacques (2016) Ambivalence: Prerequisite for success in motivational interviewing with adolescents? Addiction 111:1900-1907
Feldstein Ewing, Sarah W; Tapert, Susan F; Molina, Brooke S G (2016) Uniting adolescent neuroimaging and treatment research: Recommendations in pursuit of improved integration. Neurosci Biobehav Rev 62:109-14
Feldstein Ewing, Sarah W; Houck, Jon M; Yezhuvath, Uma et al. (2016) The impact of therapists' words on the adolescent brain: In the context of addiction treatment. Behav Brain Res 297:359-69

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