FUNDED PROJECT ABSTRACT Alcohol misuse remains a major public health problem in emerging adults (age 18-25). Excessive drinking is the largest source of morbidity and mortality in this age group and also predicts subsequent alcohol problems across the lifespan. A large number of cross-sectional studies have found significant associations between alcohol misuse and indices from behavioral economics. Specifically, two novel behavioral economic domains - alcohol demand and proportionate alcohol-related reinforcement - have been consistently associated with alcohol misuse in emerging adults in cross-sectional and laboratory studies. These motivational measures may clarify the development of alcohol misuse, but no longitudinal studies have been conducted to date. The proposed study will use a longitudinal risk design to systematically investigate the relationship between these measures and changes in alcohol misuse in emerging adults. Specifically, the study will leverage these novel risk indicators to predict changes in drinking from age 22 to 25, a time period when many individuals `mature out' of alcohol misuse but others exhibit persistently high levels of problem drinking. To address this question, the study will assess 530 at-risk drinkers (50% male/50% female) every three months from 22 to 25 using in- person and Internet-based assessments. The study has two primary aims. The first primary aim is to predict changes in alcohol misuse in emerging adults using the novel BE measures - individually, in combination with one another, and in the context of established risk factors. The second primary aim is to examine mediating and moderating relationships. Mediational analyses will test whether the BE variables causally mediate the development of alcohol misuse over time or, alternatively, whether their influence is mediated by the established mechanisms. Moderator analyses will systematically examine differences based on college status (i.e., college vs. non-college) and other substance use. The study also has a secondary aim to inform future intervention studies. This exploratory aim is to identify the most salient periods of change and the concurrent psychosocial factors that increase or decrease the value of alcohol. Collectively, the study will leverage recent advances in behavioral economics to make major contributions to understanding of alcohol misuse over the transition to adulthood. PROPOSED ADMINISTRATIVE SUPPLEMENT ABSTRACT We propose to enrich the parent project with 70 additional African American participants to have sufficient statistical power to conduct subgroup analyses on the trajectories of white participants vs. African American participants. Epidemiological research suggests greater risk of long-term problems from drinking for African American young adults and this enrichment will allow us to directly examine the risk mechanisms in this subgroup.

Public Health Relevance

We propose to enrich a currently funded project on alcohol trajectories in emerging adults with 70 additional African American participants. This will permit us to conduct specific subgroup analyses on the trajectories of African American participants. Epidemiological research suggests greater risk of long-term problems from drinking for African American young adults and this enrichment will allow us to directly examine the risk mechanisms in this subgroup.

Agency
National Institute of Health (NIH)
Institute
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Type
Research Project (R01)
Project #
3R01AA024930-02S1
Application #
9736210
Study Section
Program Officer
Bloss, Gregory
Project Start
2018-08-10
Project End
2018-12-31
Budget Start
2018-08-10
Budget End
2018-12-31
Support Year
2
Fiscal Year
2018
Total Cost
Indirect Cost
Name
Mcmaster University
Department
Type
DUNS #
207510108
City
Hamilton
State
ON
Country
Canada
Zip Code
L8 4K1
Oshri, Assaf; Kogan, Steve M; Kwon, Josephine A et al. (2018) Impulsivity as a mechanism linking child abuse and neglect with substance use in adolescence and adulthood. Dev Psychopathol 30:417-435
Naish, Katherine R; Vedelago, Lana; MacKillop, James et al. (2018) Effects of neuromodulation on cognitive performance in individuals exhibiting addictive behaviors: A systematic review. Drug Alcohol Depend 192:338-351
Lindgren, Kristen P; Hendershot, Christian S; Ramirez, Jason J et al. (2018) A dual process perspective on advances in cognitive science and alcohol use disorder. Clin Psychol Rev :
Acuff, Samuel F; Soltis, Kathryn E; Dennhardt, Ashley A et al. (2018) Evaluating Behavioral Economic Models of Heavy Drinking Among College Students. Alcohol Clin Exp Res 42:1304-1314
Morris, Vanessa; Amlung, Michael; Kaplan, Brent A et al. (2017) Using crowdsourcing to examine behavioral economic measures of alcohol value and proportionate alcohol reinforcement. Exp Clin Psychopharmacol 25:314-321