Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Research Project (R01)
Project #
7R01AG004180-08
Application #
3115005
Study Section
Allergy and Immunology Study Section (ALY)
Project Start
1983-07-01
Project End
1992-04-30
Budget Start
1991-01-01
Budget End
1991-04-30
Support Year
8
Fiscal Year
1990
Total Cost
Indirect Cost
Name
Sidney Kimmel Cancer Center
Department
Type
DUNS #
City
San Diego
State
CA
Country
United States
Zip Code
92121
Kaveri, S V; Wang, H; Rowen, D et al. (1993) Monoclonal anti-idiotypic antibodies against human anti-thyroglobulin autoantibodies recognize idiotopes shared by disease-associated and natural anti-thyroglobulin autoantibodies. Clin Immunol Immunopathol 69:333-40
Chen, J J; Kaveri, S V; Kohler, H (1992) Cryptic T cell epitopes in polymorphic immunoglobulin regions: evidence for positive repertoire selection during fetal development. Eur J Immunol 22:3077-83
Kaveri, S V; Halpern, R; Kang, C Y et al. (1991) Antibodies of different specificities are self-binding: implication for antibody diversity. Mol Immunol 28:773-8
Halpern, R; Kaveri, S V; Kohler, H (1991) Human anti-phosphorylcholine antibodies share idiotopes and are self-binding. J Clin Invest 88:476-82
Saeki, Y; Chen, J J; Shi, L F et al. (1990) Idiotype-specific T helper clones recognize a variable H chain determinant. J Immunol 144:1625-8
Kaveri, S V; Kang, C Y; Kohler, H (1990) Natural mouse and human antibodies bind to a peptide derived from a germline VH chain. Evidence for evolutionary conserved self-binding locus. J Immunol 145:4207-13
Kaveri, S V; Halpern, R; Kang, C Y et al. (1990) Self-binding antibodies (autobodies) form specific complexes in solution. J Immunol 145:2533-8
Saeki, Y; Chen, J J; Shi, L F et al. (1989) Idiotypic intramolecular help. Induction of tumor-specific antibodies by monoclonal anti-idiotypic antibody with the help of Fc-specific T helper clones. J Immunol 142:2629-34
Chang, H C; Muller, S; Kohler, H (1989) Perturbation of the idiotypic network. II. Transfer of suppression to neonatal mice. Cell Immunol 119:373-81
Muller, S; Chang, H C; Kohler, H (1989) Perturbation of the idiotypic network. I. Induction with multiple alloantigen stimulation. Cell Immunol 119:353-72

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