Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Research Project (R01)
Project #
5R01AG004542-11
Application #
2048885
Study Section
Neurology B Subcommittee 2 (NEUB)
Project Start
1991-05-01
Project End
1997-04-30
Budget Start
1995-05-01
Budget End
1997-04-30
Support Year
11
Fiscal Year
1995
Total Cost
Indirect Cost
Name
University of Kentucky
Department
Pharmacology
Type
Schools of Medicine
DUNS #
832127323
City
Lexington
State
KY
Country
United States
Zip Code
40506
Latimer, Caitlin S; Brewer, Lawrence D; Searcy, James L et al. (2014) Vitamin D prevents cognitive decline and enhances hippocampal synaptic function in aging rats. Proc Natl Acad Sci U S A 111:E4359-66
Gant, J C; Blalock, E M; Chen, K-C et al. (2014) FK506-binding protein 1b/12.6: a key to aging-related hippocampal Ca2+ dysregulation? Eur J Pharmacol 739:74-82
Thibault, Olivier; Pancani, Tristano; Landfield, Philip W et al. (2012) Reduction in neuronal L-type calcium channel activity in a double knock-in mouse model of Alzheimer's disease. Biochim Biophys Acta 1822:546-9
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Gant, John C; Chen, Kuey-Chu; Norris, Christopher M et al. (2011) Disrupting function of FK506-binding protein 1b/12.6 induces the Ca²+-dysregulation aging phenotype in hippocampal neurons. J Neurosci 31:1693-703
Norris, Christopher M; Blalock, Eric M; Chen, Kuey-Chu et al. (2010) Hippocampal 'zipper' slice studies reveal a necessary role for calcineurin in the increased activity of L-type Ca(2+) channels with aging. Neurobiol Aging 31:328-38
Gant, John C; Thibault, Olivier (2009) Action potential throughput in aged rat hippocampal neurons: regulation by selective forms of hyperpolarization. Neurobiol Aging 30:2053-64
Rowe, Wayne B; Blalock, Eric M; Chen, Kuey-Chu et al. (2007) Hippocampal expression analyses reveal selective association of immediate-early, neuroenergetic, and myelinogenic pathways with cognitive impairment in aged rats. J Neurosci 27:3098-110
Gant, John C; Sama, Michelle M; Landfield, Philip W et al. (2006) Early and simultaneous emergence of multiple hippocampal biomarkers of aging is mediated by Ca2+-induced Ca2+ release. J Neurosci 26:3482-90
Brewer, Lawrence D; Porter, Nada M; Kerr, D Steven et al. (2006) Chronic 1alpha,25-(OH)2 vitamin D3 treatment reduces Ca2+ -mediated hippocampal biomarkers of aging. Cell Calcium 40:277-86

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