Age-Associated Alterations in Human Nk Cell System

Krishnaraj, Rajabather

Abstract

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Institute on Aging (NIA)
• Type: Research Project (R01)
• Project #: 5R01AG005717-09
• Application #: 2049326
• Study Section: Special Emphasis Panel (ZRG4-GRM (01))
• Project Start: 1989-09-29
• Project End: 1998-06-30
• Budget Start: 1996-07-01
• Budget End: 1997-06-30
• Support Year: 9
• Fiscal Year: 1996

Institution

• Name: University of Illinois at Chicago
• Department: Internal Medicine/Medicine
• Type: Schools of Medicine
• DUNS #: 121911077
• City: Chicago
• State: IL
• Country: United States
• Zip Code: 60612

Publications

Krishnaraj, R; Zaks, A; Unterman, T (1998) Relationship between plasma IGF-I levels, in vitro correlates of immunity, and human senescence. Clin Immunol Immunopathol 88:264-70

Krishnaraj, R; Svanborg, A (1993) Low natural killer cell function in disseminated aspergillosis. Scand J Infect Dis 25:537-41

Krishnaraj, R; Svanborg, A (1992) Preferential accumulation of mature NK cells during human immunosenescence. J Cell Biochem 50:386-91

Krishnaraj, R (1992) Immunosenescence of human NK cells: effects on tumor target recognition, lethal hit and interferon sensitivity. Immunol Lett 34:79-84

Krishnaraj, R (1992) Negative modulation of human NK cell activity by purinoceptors. 2. Age-associated, gender-specific partial loss of sensitivity to ATP. Cell Immunol 144:11-21

Krishnaraj, R (1991) Immunomodulation by 9-amino-1,2,3,4-tetrahydroacridine (THA): 1. Down-regulation of natural cell-mediated cytotoxicity in vitro. Immunopharmacology 22:69-76

Krishnaraj, R; Blandford, G (1988) Age-associated alterations in human natural killer cells. 2. Increased frequency of selective NK subsets. Cell Immunol 114:137-48

Krishnaraj, R; Blandford, G (1987) Age-associated alterations in human natural killer cells. 1. Increased activity as per conventional and kinetic analysis. Clin Immunol Immunopathol 45:268-85