Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Research Project (R01)
Project #
7R01AG006299-06
Application #
3117257
Study Section
Hematology Subcommittee 2 (HEM)
Project Start
1986-07-01
Project End
1994-07-31
Budget Start
1991-03-01
Budget End
1991-07-31
Support Year
6
Fiscal Year
1990
Total Cost
Indirect Cost
Name
Allegheny University of Health Sciences
Department
Type
Schools of Medicine
DUNS #
City
Philadelphia
State
PA
Country
United States
Zip Code
19129
Wang, L; Anaraki, F; Henion, T R et al. (1995) Variations in activity of the human natural anti-Gal antibody in young and elderly populations. J Gerontol A Biol Sci Med Sci 50:M227-33
Hamadeh, R M; Galili, U; Zhou, P et al. (1995) Anti-alpha-galactosyl immunoglobulin A (IgA), IgG, and IgM in human secretions. Clin Diagn Lab Immunol 2:125-31
Wang, L; Radic, M Z; Galili, U (1995) Human anti-Gal heavy chain genes. Preferential use of VH3 and the presence of somatic mutations. J Immunol 155:1276-85
Repik, P M; Strizki, J M; Galili, U (1994) Differential host-dependent expression of alpha-galactosyl epitopes on viral glycoproteins: a study of eastern equine encephalitis virus as a model. J Gen Virol 75 ( Pt 5):1177-81
Winand, R J; Devigne, J W; Meurisse, M et al. (1994) Specific stimulation of Graves' disease thyrocytes by the natural anti-Gal antibody from normal and autologous serum. J Immunol 153:1386-95
Henion, T R; Macher, B A; Anaraki, F et al. (1994) Defining the minimal size of catalytically active primate alpha 1,3 galactosyltransferase: structure-function studies on the recombinant truncated enzyme. Glycobiology 4:193-201
Galili, U (1993) Interaction of the natural anti-Gal antibody with alpha-galactosyl epitopes: a major obstacle for xenotransplantation in humans. Immunol Today 14:480-2
Winand, R J; Anaraki, F; Etienne-Decerf, J et al. (1993) Xenogeneic thyroid-stimulating hormone-like activity of the human natural anti-Gal antibody. Interaction of anti-Gal with porcine thyrocytes and with recombinant human thyroid-stimulating hormone receptors expressed on mouse cells. J Immunol 151:3923-34
Galili, U (1993) Evolution and pathophysiology of the human natural anti-alpha-galactosyl IgG (anti-Gal) antibody. Springer Semin Immunopathol 15:155-71
Galili, U; Anaraki, F; Thall, A et al. (1993) One percent of human circulating B lymphocytes are capable of producing the natural anti-Gal antibody. Blood 82:2485-93

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