Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Research Project (R01)
Project #
9R01AG007046-21
Application #
3118167
Study Section
Physical Biochemistry Study Section (PB)
Project Start
1987-02-01
Project End
1992-01-31
Budget Start
1987-02-01
Budget End
1988-01-31
Support Year
21
Fiscal Year
1987
Total Cost
Indirect Cost
Name
University of Michigan Ann Arbor
Department
Type
Schools of Medicine
DUNS #
791277940
City
Ann Arbor
State
MI
Country
United States
Zip Code
48109
Mack, C P; Hultquist, D E; Shlafer, M (1995) Myocardial flavin reductase and riboflavin: a potential role in decreasing reoxygenation injury. Biochem Biophys Res Commun 212:35-40
Betz, A L; Ren, X D; Ennis, S R et al. (1994) Riboflavin reduces edema in focal cerebral ischemia. Acta Neurochir Suppl (Wien) 60:314-7
Quandt, K S; Hultquist, D E (1994) Flavin reductase: sequence of cDNA from bovine liver and tissue distribution. Proc Natl Acad Sci U S A 91:9322-6
Xu, F; DeFilippi, L J; Ballou, D P et al. (1993) Hydrogen peroxide-dependent formation and bleaching of the higher oxidation states of bovine erythrocyte green hemeprotein. Arch Biochem Biophys 301:184-9
Xu, F; Mack, C P; Quandt, K S et al. (1993) Pyrroloquinoline quinone acts with flavin reductase to reduce ferryl myoglobin in vitro and protects isolated heart from re-oxygenation injury. Biochem Biophys Res Commun 193:434-9
Hultquist, D E; Xu, F; Quandt, K S et al. (1993) Evidence that NADPH-dependent methemoglobin reductase and administered riboflavin protect tissues from oxidative injury. Am J Hematol 42:13-8
Xu, F; Quandt, K S; Hultquist, D E (1992) Characterization of NADPH-dependent methemoglobin reductase as a heme-binding protein present in erythrocytes and liver. Proc Natl Acad Sci U S A 89:2130-4
Xu, F; Hultquist, D E (1992) Bovine erythrocyte glutathione S-transferase: purification, inhibition, and complex formation. Biochem Int 27:265-74
Xu, F; Hultquist, D E (1991) Coupling of dihydroriboflavin oxidation to the formation of the higher valence states of hemeproteins. Biochem Biophys Res Commun 181:197-203
Quandt, K S; Xu, F; Chen, P et al. (1991) Evidence that the protein components of bovine erythrocyte green heme binding protein and flavin reductase are identical. Biochem Biophys Res Commun 178:315-21

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