Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Research Project (R01)
Project #
5R01AG008109-11
Application #
2050047
Study Section
Physiological Chemistry Study Section (PC)
Program Officer
Finkelstein, David B
Project Start
1985-08-30
Project End
1999-06-30
Budget Start
1996-07-01
Budget End
1997-06-30
Support Year
11
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Boston College
Department
Biology
Type
Schools of Arts and Sciences
DUNS #
045896339
City
Chestnut Hill
State
MA
Country
United States
Zip Code
02467
Bennett, Eric J; Bjerregaard, Jens; Knapp, James E et al. (2003) Catalytic implications from the Drosophila protein L-isoaspartyl methyltransferase structure and site-directed mutagenesis. Biochemistry 42:12844-53
Chavous, D A; Jackson, F R; O'Connor, C M (2001) Extension of the Drosophila lifespan by overexpression of a protein repair methyltransferase. Proc Natl Acad Sci U S A 98:14814-8
Chavous, D A; Hake, L E; Lynch, R J et al. (2000) Translation of a unique transcript for protein isoaspartyl methyltransferase in haploid spermatids: implications for protein storage and repair. Mol Reprod Dev 56:139-44
Tarcsa, E; Szymanska, G; Lecker, S et al. (2000) Ca2+-free calmodulin and calmodulin damaged by in vitro aging are selectively degraded by 26 S proteasomes without ubiquitination. J Biol Chem 275:20295-301
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Kagan, R M; McFadden, H J; McFadden, P N et al. (1997) Molecular phylogenetics of a protein repair methyltransferase. Comp Biochem Physiol B Biochem Mol Biol 117:379-85
Szymanska, G; O'Connor, M B; O'Connor, C M (1997) Construction of an epitope-tagged calmodulin useful for the analysis of calmodulin-binding proteins: addition of a hemagglutinin epitope does not affect calmodulin-dependent activation of smooth muscle myosin light chain kinase. Anal Biochem 252:96-105
O'Connor, M B; Galus, A; Hartenstine, M et al. (1997) Structural organization and developmental expression of the protein isoaspartyl methyltransferase gene from Drosophila melanogaster. Insect Biochem Mol Biol 27:49-54
O'Connor, C M (1994) Analysis of aspartic acid and asparagine metabolism in Xenopus laevis oocytes using a simple and sensitive HPLC method. Mol Reprod Dev 39:392-6

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