Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Research Project (R01)
Project #
7R01AG008193-02
Application #
3119673
Study Section
(SRC)
Project Start
1988-07-01
Project End
1991-07-31
Budget Start
1989-08-01
Budget End
1990-07-31
Support Year
2
Fiscal Year
1989
Total Cost
Indirect Cost
Name
University of Maryland Baltimore
Department
Type
Schools of Medicine
DUNS #
003255213
City
Baltimore
State
MD
Country
United States
Zip Code
21201
Lu, Yi-Feng; Cerny, Jan (2002) Repertoire of antibody response in bone marrow and the memory response are differentially affected in aging mice. J Immunol 169:4920-7
Lu, Y F; Singh, M; Cerny, J (2001) Canonical germinal center B cells may not dominate the memory response to antigenic challenge. Int Immunol 13:643-55
Nie, X; Basu, S; Cerny, J (1997) Immunization with immune complex alters the repertoire of antigen-reactive B cells in the germinal centers. Eur J Immunol 27:3517-25
Lahvis, G P; Cerny, J (1997) Induction of germinal center B cell markers in vitro by activated CD4+ T lymphocytes: the role of CD40 ligand, soluble factors, and B cell antigen receptor cross-linking. J Immunol 159:1783-93
Yang, X; Stedra, J; Cerny, J (1996) Relative contribution of T and B cells to hypermutation and selection of the antibody repertoire in germinal centers of aged mice. J Exp Med 183:959-70
Miller, C; Stedra, J; Kelsoe, G et al. (1995) Facultative role of germinal centers and T cells in the somatic diversification of IgVH genes. J Exp Med 181:1319-31
Yang, X; Stedra, J; Cerny, J (1994) Repertoire diversity of antibody response to bacterial antigens in aged mice. IV. Study of VH and VL gene utilization in splenic antibody foci by in situ hybridization. J Immunol 152:2214-21
Stedra, J; Cerny, J (1994) Distinct pathways of B cell differentiation. I. Residual T cells in athymic mice support the development of splenic germinal centers and B cell memory without an induction of antibody. J Immunol 152:1718-26
Nicoletti, C; Yang, X; Cerny, J (1993) Repertoire diversity of antibody response to bacterial antigens in aged mice. III. Phosphorylcholine antibody from young and aged mice differ in structure and protective activity against infection with Streptococcus pneumoniae. J Immunol 150:543-9
Nicoletti, C; Borghesi-Nicoletti, C; Yang, X H et al. (1991) Repertoire diversity of antibody response to bacterial antigens in aged mice. II. Phosphorylcholine-antibody in young and aged mice differ in both VH/VL gene repertoire and in specificity. J Immunol 147:2750-5

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