The primary goals of this proposal are to quantify regional mu-opiate receptors and glucose metabolism in possible and probable Alzheimer's Disease and normal controls by positron emission tomography (PET) and to relate abnormalities of neuropsychological parameters in Alzheimer's Disease to PET findings. Additionally, we will determine the specificity of changes in mu-opiate receptors to Alzheimer's Disease by examining Multi Infarct Dementia patients in a similar manner. These results will 1) improve our understanding of the basic pathophysiology of Alzheimer's Disease, 2) relate parameters of cognitive decline to neurochemistry and 3) possible lead to earlier diagnosis of Alzheimer's Disease through quantification of mu-opiate receptors than possible by clinical examination or by measuring glucose metabolism.

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Research Project (R01)
Project #
5R01AG008740-04
Application #
3120489
Study Section
Diagnostic Radiology Study Section (RNM)
Project Start
1990-04-01
Project End
1995-03-31
Budget Start
1993-04-10
Budget End
1994-03-31
Support Year
4
Fiscal Year
1993
Total Cost
Indirect Cost
Name
Johns Hopkins University
Department
Type
Schools of Medicine
DUNS #
045911138
City
Baltimore
State
MD
Country
United States
Zip Code
21218
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Frost, J J; Rosier, A J; Reich, S G et al. (1993) Positron emission tomographic imaging of the dopamine transporter with 11C-WIN 35,428 reveals marked declines in mild Parkinson's disease. Ann Neurol 34:423-31
Price, J C; Mayberg, H S; Dannals, R F et al. (1993) Measurement of benzodiazepine receptor number and affinity in humans using tracer kinetic modeling, positron emission tomography, and [11C]flumazenil. J Cereb Blood Flow Metab 13:656-67
Frost, J J (1992) Receptor imaging by positron emission tomography and single-photon emission computed tomography. Invest Radiol 27 Suppl 2:S54-8
Muller-Gartner, H W; Links, J M; Prince, J L et al. (1992) Measurement of radiotracer concentration in brain gray matter using positron emission tomography: MRI-based correction for partial volume effects. J Cereb Blood Flow Metab 12:571-83

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