Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Research Project (R01)
Project #
5R01AG008991-03
Application #
3120796
Study Section
Molecular Cytology Study Section (CTY)
Project Start
1990-05-01
Project End
1992-06-30
Budget Start
1992-05-01
Budget End
1992-06-30
Support Year
3
Fiscal Year
1992
Total Cost
Indirect Cost
Name
Massachusetts Institute of Technology
Department
Type
Schools of Arts and Sciences
DUNS #
City
Cambridge
State
MA
Country
United States
Zip Code
02139
Madura, K; Dohmen, R J; Varshavsky, A (1993) N-recognin/Ubc2 interactions in the N-end rule pathway. J Biol Chem 268:12046-54
Shrader, T E; Tobias, J W; Varshavsky, A (1993) The N-end rule in Escherichia coli: cloning and analysis of the leucyl, phenylalanyl-tRNA-protein transferase gene aat. J Bacteriol 175:4364-74
Larsen, P L (1993) Aging and resistance to oxidative damage in Caenorhabditis elegans. Proc Natl Acad Sci U S A 90:8905-9
Baker, R T; Tobias, J W; Varshavsky, A (1992) Ubiquitin-specific proteases of Saccharomyces cerevisiae. Cloning of UBP2 and UBP3, and functional analysis of the UBP gene family. J Biol Chem 267:23364-75
Johnson, E S; Bartel, B; Seufert, W et al. (1992) Ubiquitin as a degradation signal. EMBO J 11:497-505
Baker, R T; Varshavsky, A (1991) Inhibition of the N-end rule pathway in living cells. Proc Natl Acad Sci U S A 88:1090-4
Ellison, M J; Hochstrasser, M (1991) Epitope-tagged ubiquitin. A new probe for analyzing ubiquitin function. J Biol Chem 266:21150-7
Tobias, J W; Varshavsky, A (1991) Cloning and functional analysis of the ubiquitin-specific protease gene UBP1 of Saccharomyces cerevisiae. J Biol Chem 266:12021-8
Hochstrasser, M; Ellison, M J; Chau, V et al. (1991) The short-lived MAT alpha 2 transcriptional regulator is ubiquitinated in vivo. Proc Natl Acad Sci U S A 88:4606-10