Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Research Project (R01)
Project #
5R01AG009278-06
Application #
2050700
Study Section
Molecular Cytology Study Section (CTY)
Project Start
1994-09-30
Project End
1999-08-31
Budget Start
1996-09-01
Budget End
1997-08-31
Support Year
6
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Mcgill University
Department
Type
DUNS #
City
Montreal
State
PQ
Country
Canada
Zip Code
H3 0-G4
Marcotte, Richard; Qian, Jing-Fang; Chen, James et al. (2003) hMad4, c-Myc endogenous inhibitor, induces a replicative senescence-like state when overexpressed in human fibroblasts. J Cell Biochem 89:576-88
Semov, Alexandre; Marcotte, Richard; Semova, Natalie et al. (2002) Microarray analysis of E-box binding-related gene expression in young and replicatively senescent human fibroblasts. Anal Biochem 302:38-51
Wang, E; Marcotte, R; Petroulakis, E (1999) Signaling pathway for apoptosis: a racetrack for life or death. J Cell Biochem Suppl 32-33:95-102
Wang, E (1999) Age-dependent atrophy and microgravity travel: what do they have in common? FASEB J 13 Suppl:S167-74
Bernier, L; Wang, E (1996) A prospective view on phosphatases and replicative senescence. Exp Gerontol 31:13-9
Wang, E; Liu, D (1996) Characterization of senescence- and apoptosis-dependent forms of terminin as derived from a precursor found in replicating and nonreplicating cells. J Cell Biochem 60:107-20
Warner, H R; Fernandes, G; Wang, E (1995) A unifying hypothesis to explain the retardation of aging and tumorigenesis by caloric restriction. J Gerontol A Biol Sci Med Sci 50:B107-9
Wang, E; Pandey, S (1995) Down-regulation of statin, a nonproliferation-specific nuclear protein, and up-regulation of c-myc after initiation of programmed cell death in mouse fibroblasts. J Cell Physiol 163:155-63
Pandey, S; Wang, E (1995) Cells en route to apoptosis are characterized by the upregulation of c-fos, c-myc, c-jun, cdc2, and RB phosphorylation, resembling events of early cell-cycle traverse. J Cell Biochem 58:135-50
Wang, E (1995) Senescent human fibroblasts resist programmed cell death, and failure to suppress bcl2 is involved. Cancer Res 55:2284-92

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