Osteoarthritis (OA) is the most common joint disorder. Radiographic changes of OA occur in most people by 65 years of age and are present in more than 80% of people over age 85. OA is most common in the hands and is also common in the knees where symptoms are often severe. Studies looking at the causes of OA and the increase in OA with age have in general been cross-sectional. There have been few attempts to follow individuals over time to assess disease development. The objective of this project is to examine the long term course and risk factors for osteoarthritis. Specifically, we will look at the natural history of OA in a population based group of elderly, the Framingham Heart Study cohort. This group obtained hand X-rays 25 years ago and knee x-rays 8 years ago as part of the Framingham OA Study. The investigators propose to do a follow-up study.
The specific aims of this project are to look at the natural history of disease and risk factors for OA. This study would involve interviews with subjects along with physical examinations and x-rays of the knees and hands. The analyses would focus on whether OA has developed or progressed since the first exam. For those with new or progressive knee OA or hand OA, the investigators propose to examine what risk factors might have caused disease. They will focus on age, sex, obesity, chondrocalcinosis, and osteopenia as identified by bone mass studies also being performed in the group. They would also investigate potential new risk factors including walking activity, knee alignment, and hormones (including gonadal hormones and insulin-like growth factor I). Also, they would look at whether there is a generalized disease process in subjects after controlling for known causes of disease and investigate whether subjects with hand or knee OA tend to develop OA in the other site more frequently. Because it is longitudinal, the investigators believe that the project offers potentially new and important insights into all aspects of OA epidemiology. They state that the study of natural history may identify subgroups in whom disease is likely to develop or progress. They also state that the study of risk factors will be uniquely valuable because it is longitudinal and the proposed inquiry into potential unstudied risk factors may yield major new insights into causes of disease.

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Research Project (R01)
Project #
1R01AG009300-01A1
Application #
3121134
Study Section
Epidemiology and Disease Control Subcommittee 2 (EDC)
Project Start
1991-06-01
Project End
1996-04-30
Budget Start
1991-06-01
Budget End
1992-04-30
Support Year
1
Fiscal Year
1991
Total Cost
Indirect Cost
Name
Boston University
Department
Type
Schools of Medicine
DUNS #
604483045
City
Boston
State
MA
Country
United States
Zip Code
02118
Stefanik, J J; Niu, J; Gross, K D et al. (2013) Using magnetic resonance imaging to determine the compartmental prevalence of knee joint structural damage. Osteoarthritis Cartilage 21:695-9
Edmond, Susan L; Felson, David T (2003) Function and back symptoms in older adults. J Am Geriatr Soc 51:1702-9
LaValley, M; McAlindon, T E; Evans, S et al. (2001) Problems in the development and validation of questionnaire-based screening instruments for ascertaining cases with symptomatic knee osteoarthritis: the Framingham Study. Arthritis Rheum 44:1105-13
LaValley, M P; McAlindon, T E; Chaisson, C E et al. (2001) The validity of different definitions of radiographic worsening for longitudinal studies of knee osteoarthritis. J Clin Epidemiol 54:30-9
Edmond, S L; Felson, D T (2000) Prevalence of back symptoms in elders. J Rheumatol 27:220-5
Zhang, Y; Hannan, M T; Chaisson, C E et al. (2000) Bone mineral density and risk of incident and progressive radiographic knee osteoarthritis in women: the Framingham Study. J Rheumatol 27:1032-7
Fraenkel, L; Zhang, Y; Chaisson, C E et al. (1999) Different factors influencing the expression of Raynaud's phenomenon in men and women. Arthritis Rheum 42:306-10
McAlindon, T E; Wilson, P W; Aliabadi, P et al. (1999) Level of physical activity and the risk of radiographic and symptomatic knee osteoarthritis in the elderly: the Framingham study. Am J Med 106:151-7
Felson, D T; Nevitt, M C (1999) Estrogen and osteoarthritis: how do we explain conflicting study results? Prev Med 28:445-8;discussion 449-50
Felson, D T; Couropmitree, N N; Chaisson, C E et al. (1998) Evidence for a Mendelian gene in a segregation analysis of generalized radiographic osteoarthritis: the Framingham Study. Arthritis Rheum 41:1064-71

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