Protein Glycation by Acyl Glucuronides in the Elderly

Smith, Philip J.

Abstract

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Institute on Aging (NIA)
• Type: Research Project (R01)
• Project #: 7R01AG009594-03
• Application #: 3121484
• Study Section: General Medicine B Study Section (GMB)
• Project Start: 1992-08-01
• Project End: 1995-01-31
• Budget Start: 1992-12-01
• Budget End: 1993-01-31
• Support Year: 3
• Fiscal Year: 1992

Institution

• Name: University of North Carolina Chapel Hill
• Type: Schools of Medicine
• DUNS #: 078861598
• City: Chapel Hill
• State: NC
• Country: United States
• Zip Code: 27599

Publications

Liu, J H; Marquez, C D; Weintraub, S T et al. (1998) Reaction of acyl glucuronides with insulin in vitro: identification of an imine mechanism by electrospray ionization mass spectrometry. Pharm Res 15:343-6

Castillo, M; Smith, P C (1995) Disposition and reactivity of ibuprofen and ibufenac acyl glucuronides in vivo in the rhesus monkey and in vitro with human serum albumin. Drug Metab Dispos 23:566-72

Smith, P C; Liu, J H (1993) Covalent binding of suprofen acyl glucuronide to albumin in vitro. Xenobiotica 23:337-48

Smith, P C; Song, W Q; Rodriguez, R J (1992) Covalent binding of etodolac acyl glucuronide to albumin in vitro. Drug Metab Dispos 20:962-5

Smith, P C; Wang, C (1992) Nonenzymic glycation of albumin by acyl glucuronides in vitro. Comparison of reactions with reducing sugars. Biochem Pharmacol 44:1661-8