Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Research Project (R01)
Project #
5R01AG010528-03
Application #
2051758
Study Section
Neurology A Study Section (NEUA)
Project Start
1994-08-01
Project End
1998-07-31
Budget Start
1996-08-01
Budget End
1997-07-31
Support Year
3
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of Minnesota Twin Cities
Department
Psychiatry
Type
Schools of Medicine
DUNS #
168559177
City
Minneapolis
State
MN
Country
United States
Zip Code
55455
Vatassery, G T; Bauer, T; Dysken, M (1999) High doses of vitamin E in the treatment of disorders of the central nervous system in the aged. Am J Clin Nutr 70:793-801
Vatassery, G T (1998) Vitamin E and other endogenous antioxidants in the central nervous system. Geriatrics 53 Suppl 1:S25-7
Vatassery, G T; Smith, W E; Quach, H T (1998) Alpha-tocopherol in rat brain subcellular fractions is oxidized rapidly during incubations with low concentrations of peroxynitrite. J Nutr 128:152-7
Vatassery, G T; Fahn, S; Kuskowski, M A (1998) Alpha tocopherol in CSF of subjects taking high-dose vitamin E in the DATATOP study. Parkinson Study Group. Neurology 50:1900-2
Vatassery, G T; Lai, J C; Smith, W E et al. (1998) Aging is associated with a decrease in synaptosomal glutamate uptake and an increase in the susceptibility of synaptosomal vitamin E to oxidative stress. Neurochem Res 23:121-5
Vatassery, G T; Quach, H T; Smith, W E et al. (1997) Oxidation of cholesterol in synaptosomes and mitochondria isolated from rat brains. Lipids 32:879-86
Vatassery, G T; Quach, H T; Smith, W E et al. (1997) Analysis of hydroxy and keto cholesterols in oxidized brain synaptosomes. Lipids 32:101-7
Vatassery, G T (1996) Oxidation of vitamin E, vitamin C, and thiols in rat brain synaptosomes by peroxynitrite. Biochem Pharmacol 52:579-86
Vatassery, G T (1995) In vitro oxidation of vitamins C and E, cholesterol, and thiols in rat brain synaptosomes. Lipids 30:1007-13
Vatassery, G T; Smith, W E; Quach, H T et al. (1995) In vitro oxidation of vitamin E, vitamin C, thiols and cholesterol in rat brain mitochondria incubated with free radicals. Neurochem Int 26:527-35