Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Research Project (R01)
Project #
3R01AG011060-04S1
Application #
2052274
Study Section
Biological and Clinical Aging Review Committee (BCA)
Project Start
1993-05-01
Project End
1998-03-31
Budget Start
1996-04-15
Budget End
1997-03-31
Support Year
4
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Allegheny University of Health Sciences
Department
Pharmacology
Type
Schools of Medicine
DUNS #
City
Philadelphia
State
PA
Country
United States
Zip Code
19129
Gao, E; Snyder, D L; Roberts, J et al. (1998) Age-related decline in beta adrenergic and adenosine A1 receptor function in the heart are attenuated by dietary restriction. J Pharmacol Exp Ther 285:186-92
Snyder, D L; Aloyo, V J; Wang, W et al. (1998) Influence of age and dietary restriction on norepinephrine uptake into cardiac synaptosomes. J Cardiovasc Pharmacol 32:896-901
Snyder, D L; Gayheart-Walsten, P A; Rhie, S et al. (1998) Effect of age, gender, rat strain, and dietary restriction, on norepinephrine release from cardiac synaptosomes. J Gerontol A Biol Sci Med Sci 53:B33-41
Snyder, D L; Wang, W; Pelleg, A et al. (1998) Effect of aging on A1-adenosine receptor-mediated inhibition of norepinephrine release in the rat heart. J Cardiovasc Pharmacol 31:352-8
Cai, G; Wang, H Y; Gao, E et al. (1997) Reduced adenosine A1 receptor and G alpha protein coupling in rat ventricular myocardium during aging. Circ Res 81:1065-71
Gao, E; Snyder, D L; Johnson, M D et al. (1997) The effect of age on adenosine A1 receptor function in the rat heart. J Mol Cell Cardiol 29:593-602
Gurdal, H; Tilakaratne, N; Brown, R D et al. (1995) The expression of alpha 1 adrenoceptor subtypes changes with age in the rat aorta. J Pharmacol Exp Ther 275:1656-62
Gayheart-Walsten, P; Snyder, D; Mack, J et al. (1995) Scintigraphic imaging with 123I-metaiodobenzylguanidine as a marker of cardiac adrenergic neurotransmission in the rat. Methods Find Exp Clin Pharmacol 17:249-54
Gurdal, H; Friedman, E; Johnson, M D (1995) Effects of dietary restriction on the change in aortic alpha 1-adrenoceptor mediated responses during aging in Fischer 344 rats. J Gerontol A Biol Sci Med Sci 50:B67-71
Gurdal, H; Friedman, E; Johnson, M D (1995) Beta-adrenoceptor-G alpha S coupling decreases with age in rat aorta. Mol Pharmacol 47:772-8

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