Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Research Project (R01)
Project #
3R01AG011227-03S1
Application #
2052429
Study Section
Biochemical Endocrinology Study Section (BCE)
Project Start
1993-01-01
Project End
1997-12-31
Budget Start
1996-03-01
Budget End
1997-12-31
Support Year
3
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Virginia Commonwealth University
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
City
Richmond
State
VA
Country
United States
Zip Code
23298
Lavallee, B; Provost, P R; Kahwash, Z et al. (1997) Effect of insulin on serum levels of dehydroepiandrosterone metabolites in men. Clin Endocrinol (Oxf) 46:93-100
Jakubowicz, D J; Nestler, J E (1997) 17 alpha-Hydroxyprogesterone responses to leuprolide and serum androgens in obese women with and without polycystic ovary syndrome offer dietary weight loss. J Clin Endocrinol Metab 82:556-60
Nestler, J E (1997) Insulin regulation of human ovarian androgens. Hum Reprod 12 Suppl 1:53-62
Nestler, J E; Jakubowicz, D J (1996) Decreases in ovarian cytochrome P450c17 alpha activity and serum free testosterone after reduction of insulin secretion in polycystic ovary syndrome. N Engl J Med 335:617-23
Beer, N A; Jakubowicz, D J; Matt, D W et al. (1996) Dehydroepiandrosterone reduces plasma plasminogen activator inhibitor type 1 and tissue plasminogen activator antigen in men. Am J Med Sci 311:205-10
Jakubowicz, D J; Beer, N A; Beer, R M et al. (1995) Disparate effects of weight reduction by diet on serum dehydroepiandrosterone-sulfate levels in obese men and women. J Clin Endocrinol Metab 80:3373-6
Jesse, R L; Loesser, K; Eich, D M et al. (1995) Dehydroepiandrosterone inhibits human platelet aggregation in vitro and in vivo. Ann N Y Acad Sci 774:281-90
Nestler, J E; Beer, N A; Jakubowicz, D J et al. (1995) Effects of insulin reduction with benfluorex on serum dehydroepiandrosterone (DHEA), DHEA sulfate, and blood pressure in hypertensive middle-aged and elderly men. J Clin Endocrinol Metab 80:700-6
Nestler, J E (1995) Regulation of human dehydroepiandrosterone metabolism by insulin. Ann N Y Acad Sci 774:73-81
Nestler, J E; Beer, N A; Jakubowicz, D J et al. (1994) Effects of a reduction in circulating insulin by metformin on serum dehydroepiandrosterone sulfate in nondiabetic men. J Clin Endocrinol Metab 78:549-54

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