Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Research Project (R01)
Project #
5R01AG011475-04
Application #
2052659
Study Section
Immunobiology Study Section (IMB)
Project Start
1993-04-01
Project End
1998-03-31
Budget Start
1996-04-01
Budget End
1998-03-31
Support Year
4
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of Utah
Department
Pathology
Type
Schools of Medicine
DUNS #
City
Salt Lake City
State
UT
Country
United States
Zip Code
84112
Poynter, M E; Daynes, R A (1999) Age-associated alterations in splenic iNOS regulation: influence of constitutively expressed IFN-gamma and correction following supplementation with PPARalpha activators or vitamin E. Cell Immunol 195:127-36
Poynter, M E; Daynes, R A (1998) Peroxisome proliferator-activated receptor alpha activation modulates cellular redox status, represses nuclear factor-kappaB signaling, and reduces inflammatory cytokine production in aging. J Biol Chem 273:32833-41
Hennebold, J D; Daynes, R A (1998) Inhibition of skin 11beta-hydroxysteroid dehydrogenase activity in vivo potentiates the anti-inflammatory actions of glucocorticoids. Arch Dermatol Res 290:413-9
Spencer, N F; Daynes, R A (1997) IL-12 directly stimulates expression of IL-10 by CD5+ B cells and IL-6 by both CD5+ and CD5- B cells: possible involvement in age-associated cytokine dysregulation. Int Immunol 9:745-54
Poynter, M E; Mu, H H; Chen, X P et al. (1997) Activation of NK1.1+ T cells in vitro and their possible role in age-associated changes in inducible IL-4 production. Cell Immunol 179:22-9
Hennebold, J D; Mu, H H; Poynter, M E et al. (1997) Active catabolism of glucocorticoids by 11 beta-hydroxysteroid dehydrogenase in vivo is a necessary requirement for natural resistance to infection with Listeria monocytogenes. Int Immunol 9:105-15
Spencer, N F; Poynter, M E; Im, S Y et al. (1997) Constitutive activation of NF-kappa B in an animal model of aging. Int Immunol 9:1581-8
Chen, X P; Enioutina, E Y; Daynes, R A (1997) The control of IL-4 gene expression in activated murine T lymphocytes: a novel role for neu-1 sialidase. J Immunol 158:3070-80
Spencer, N F; Norton, S D; Harrison, L L et al. (1996) Dysregulation of IL-10 production with aging: possible linkage to the age-associated decline in DHEA and its sulfated derivative. Exp Gerontol 31:393-408
Hennebold, J D; Ryu, S Y; Mu, H H et al. (1996) 11 beta-hydroxysteroid dehydrogenase modulation of glucocorticoid activities in lymphoid organs. Am J Physiol 270:R1296-306

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