Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Research Project (R01)
Project #
5R01AG011899-03
Application #
2053164
Study Section
Neurological Sciences Subcommittee 1 (NLS)
Project Start
1994-01-01
Project End
1996-12-31
Budget Start
1996-02-20
Budget End
1996-12-31
Support Year
3
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Massachusetts General Hospital
Department
Type
DUNS #
City
Boston
State
MA
Country
United States
Zip Code
02199
McNamara, M J; Ruff, C T; Wasco, W et al. (1998) Immunohistochemical and in situ analysis of amyloid precursor-like protein-1 and amyloid precursor-like protein-2 expression in Alzheimer disease and aged control brains. Brain Res 804:45-51
Kovacs, D M; Wasco, W; Witherby, J et al. (1995) The upstream stimulatory factor functionally interacts with the Alzheimer amyloid beta-protein precursor gene. Hum Mol Genet 4:1527-33
Kim, T W; Wu, K; Xu, J L et al. (1995) Selective localization of amyloid precursor-like protein 1 in the cerebral cortex postsynaptic density. Brain Res Mol Brain Res 32:36-44
Levy-Lahad, E; Wasco, W; Poorkaj, P et al. (1995) Candidate gene for the chromosome 1 familial Alzheimer's disease locus. Science 269:973-7
Bush, A I; Pettingell Jr, W H; de Paradis, M et al. (1994) The amyloid beta-protein precursor and its mammalian homologues. Evidence for a zinc-modulated heparin-binding superfamily. J Biol Chem 269:26618-21
Bush, A I; Pettingell, W H; Multhaup, G et al. (1994) Rapid induction of Alzheimer A beta amyloid formation by zinc. Science 265:1464-7