Abstract

Recently an association has been noted between a particular allele (epsilon4) of the APOE locus and Alzheimer's disease (AD) in samples of patients selected for study at an AD research center. Such samples are highly selected either for family studies or for clear diagnoses of AD. We wish to determine the allele frequencies at the APOE locus in an epidemiologically ascertained AD sample compared to controls from the same population. This will validate the findings of previous studies and will determine the true risk of AD conferred by alleles at this locus. We will also examine allele frequencies in other dementias from the same population. We will investigate the relationship between APOE genotypes and age of onset and progression in both the epidemiologic sample and a large cohort of AD families ascertained for genetic linkage studies.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Research Project (R01)
Project #
5R01AG012412-02
Application #
2054015
Study Section
Epidemiology and Disease Control Subcommittee 2 (EDC)
Project Start
1994-09-01
Project End
1997-06-30
Budget Start
1995-07-01
Budget End
1996-06-30
Support Year
2
Fiscal Year
1995
Total Cost
Indirect Cost

  Institution

Name
University of South Florida
Department
Psychiatry
Type
Schools of Medicine
DUNS #
City
Tampa
State
FL
Country
United States
Zip Code
33612

  Publications

Town, T; Paris, D; Parker, T A et al. (1999) Alzheimers disease is not associated with the hypertension genetic risk factors PLA(2) or G protein beta3, either independently or interactively with apolipoprotein E. Am J Med Genet 88:465-8
Crawford, F; Freeman, M; Town, T et al. (1999) No genetic association between polymorphisms in the Tau gene and Alzheimer's disease in clinic or population based samples. Neurosci Lett 266:193-6
Crawford, F; Fallin, D; Suo, Z et al. (1998) The butyrylcholinesterase gene is neither independently nor synergistically associated with late-onset AD in clinic- and community-based populations. Neurosci Lett 249:115-8
Cai, X; Stanton, J; Fallin, D et al. (1997) No association between the intronic presenilin-1 polymorphism and Alzheimer's disease in clinic and population-based samples. Am J Med Genet 74:202-3
Cai, X; Fallin, D; Stanton, J et al. (1997) APOE is linked to Alzheimer's disease in a large pedigree. Am J Med Genet 74:365-9
Fallin, D; Gauntlett, A C; Scibelli, P et al. (1997) No association between the very low density lipoprotein receptor gene and late-onset Alzheimer's disease nor interaction with the apolipoprotein E gene in population-based and clinic samples. Genet Epidemiol 14:299-305
Fallin, D; Reading, S; Schinka, J et al. (1997) No interaction between the APOE and the alpha-1-antichymotrypsin genes on risk for Alzheimer's disease. Am J Med Genet 74:192-4
Fallin, D; Kundtz, A; Town, T et al. (1997) No association between the low density lipoprotein receptor-related protein (LRP) gene and late-onset Alzheimer's disease in a community-based sample. Neurosci Lett 233:145-7