Factors Governing Alzheimers Alpha/Beta Protein

Younkin, Steven G.

Abstract

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Institute on Aging (NIA)
• Type: Research Project (R01)
• Project #: 3R01AG012685-05S2
• Application #: 2690526
• Study Section: Neurological Sciences Subcommittee 1 (NLS)
• Project Start: 1994-05-01
• Project End: 1999-03-31
• Budget Start: 1997-12-01
• Budget End: 1998-03-31
• Support Year: 5
• Fiscal Year: 1998

Institution

• Name: Mayo Clinic, Rochester
• City: Rochester
• State: MN
• Country: United States
• Zip Code: 55905

Publications

Huang, Xudong; Atwood, Craig S; Moir, Robert D et al. (2004) Trace metal contamination initiates the apparent auto-aggregation, amyloidosis, and oligomerization of Alzheimer's Abeta peptides. J Biol Inorg Chem 9:954-60

Opazo, Carlos; Huang, Xudong; Cherny, Robert A et al. (2002) Metalloenzyme-like activity of Alzheimer's disease beta-amyloid. Cu-dependent catalytic conversion of dopamine, cholesterol, and biological reducing agents to neurotoxic H(2)O(2). J Biol Chem 277:40302-8

Carlson, G A; Borchelt, D R; Dake, A et al. (1997) Genetic modification of the phenotypes produced by amyloid precursor protein overexpression in transgenic mice. Hum Mol Genet 6:1951-9

Gravina, S A; Ho, L; Eckman, C B et al. (1995) Amyloid beta protein (A beta) in Alzheimer's disease brain. Biochemical and immunocytochemical analysis with antibodies specific for forms ending at A beta 40 or A beta 42(43). J Biol Chem 270:7013-6