Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Research Project (R01)
Project #
1R01AG013081-01A2
Application #
2054992
Study Section
Special Emphasis Panel (ZRG4-GRM (01))
Project Start
1996-08-01
Project End
1999-07-31
Budget Start
1996-08-01
Budget End
1997-07-31
Support Year
1
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of Arkansas for Medical Sciences
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
City
Little Rock
State
AR
Country
United States
Zip Code
72205
Ponnappan, Subramaniam; Ponnappan, Usha (2011) Aging and immune function: molecular mechanisms to interventions. Antioxid Redox Signal 14:1551-85
Cullen, Sarah J; Ponnappan, Subramaniam; Ponnappan, Usha (2010) Proteasome inhibition up-regulates inflammatory gene transcription induced by an atypical pathway of NF-kappaB activation. Biochem Pharmacol 79:706-14
Cullen, Sarah J; Ponnappan, Subramaniam; Ponnappan, Usha (2009) Catalytic activity of the proteasome fine-tunes Brg1-mediated chromatin remodeling to regulate the expression of inflammatory genes. Mol Immunol 47:600-5
Sun, Lu; Hodeify, Rawad; Haun, Shirley et al. (2008) Ca2+ homeostasis regulates Xenopus oocyte maturation. Biol Reprod 78:726-35
Das, Rupali; Ponnappan, Subramaniam; Ponnappan, Usha (2007) Redox regulation of the proteasome in T lymphocytes during aging. Free Radic Biol Med 42:541-51
Ponnappan, Subramaniam; Ovaa, Huib; Ponnappan, Usha (2007) Lower expression of catalytic and structural subunits of the proteasome contributes to decreased proteolysis in peripheral blood T lymphocytes during aging. Int J Biochem Cell Biol 39:799-809
Ponnappan, Subramaniam; Cullen, Sarah J; Ponnappan, Usha (2005) Constitutive degradation of IkappaBalpha in human T lymphocytes is mediated by calpain. Immun Ageing 2:15
Ponnappan, Subramaniam; Uken-Trebilcock, Gina; Lindquist, Michael et al. (2004) Tyrosine phosphorylation-dependent activation of NFkappaB is compromised in T cells from the elderly. Exp Gerontol 39:559-66
Ponnappan, Usha (2002) Ubiquitin-proteasome pathway is compromised in CD45RO+ and CD45RA+ T lymphocyte subsets during aging. Exp Gerontol 37:359-67
Ponnappan, U; Soderberg, L S (2001) Inflammatory macrophage nuclear factor-kappaB and proteasome activity are inhibited following exposure to inhaled isobutyl nitrite. J Leukoc Biol 69:639-44

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