Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Research Project (R01)
Project #
1R01AG013726-01
Application #
2055723
Study Section
Hematology Subcommittee 2 (HEM)
Project Start
1996-04-09
Project End
1996-12-31
Budget Start
1996-04-09
Budget End
1996-12-31
Support Year
1
Fiscal Year
1996
Total Cost
Indirect Cost
Name
St. Jude Children's Research Hospital
Department
Type
DUNS #
067717892
City
Memphis
State
TN
Country
United States
Zip Code
38105
Hiebert, Scott W; Reed-Inderbitzin, Edward F; Amann, Joseph et al. (2003) The t(8;21) fusion protein contacts co-repressors and histone deacetylases to repress the transcription of the p14ARF tumor suppressor. Blood Cells Mol Dis 30:177-83
Linggi, Bryan; Muller-Tidow, Carsten; van de Locht, Louis et al. (2002) The t(8;21) fusion protein, AML1 ETO, specifically represses the transcription of the p14(ARF) tumor suppressor in acute myeloid leukemia. Nat Med 8:743-50
Amann, J M; Nip, J; Strom, D K et al. (2001) ETO, a target of t(8;21) in acute leukemia, makes distinct contacts with multiple histone deacetylases and binds mSin3A through its oligomerization domain. Mol Cell Biol 21:6470-83
Nip, J; Strom, D K; Eischen, C M et al. (2001) E2F-1 induces the stabilization of p53 but blocks p53-mediated transactivation. Oncogene 20:910-20
Nip, J; Hiebert, S W (2000) Topoisomerase IIalpha mediates E2F-1-induced chemosensitivity and is a target for p53-mediated transcriptional repression. Cell Biochem Biophys 33:199-207
Lutterbach, B; Westendorf, J J; Linggi, B et al. (2000) A mechanism of repression by acute myeloid leukemia-1, the target of multiple chromosomal translocations in acute leukemia. J Biol Chem 275:651-6
Strom, D K; Nip, J; Westendorf, J J et al. (2000) Expression of the AML-1 oncogene shortens the G(1) phase of the cell cycle. J Biol Chem 275:3438-45
Westendorf, J J; Mernaugh, R; Hiebert, S W (1999) Identification and characterization of a protein containing formin homology (FH1/FH2) domains. Gene 232:173-82
Strom, D K; Cleveland, J L; Chellappan, S et al. (1998) E2F-1 and E2F-3 are functionally distinct in their ability to promote myeloid cell cycle progression and block granulocyte differentiation. Cell Growth Differ 9:59-69
Lutterbach, B; Westendorf, J J; Linggi, B et al. (1998) ETO, a target of t(8;21) in acute leukemia, interacts with the N-CoR and mSin3 corepressors. Mol Cell Biol 18:7176-84

Showing the most recent 10 out of 13 publications