Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Research Project (R01)
Project #
1R01AG013939-01
Application #
2001914
Study Section
Neurological Sciences Subcommittee 1 (NLS)
Project Start
1996-09-19
Project End
2000-06-30
Budget Start
1996-09-19
Budget End
1997-06-30
Support Year
1
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Northwestern University at Chicago
Department
Anatomy/Cell Biology
Type
Schools of Medicine
DUNS #
005436803
City
Chicago
State
IL
Country
United States
Zip Code
60611
Barone, Eugenio; Di Domenico, Fabio; Sultana, Rukhsana et al. (2012) Heme oxygenase-1 posttranslational modifications in the brain of subjects with Alzheimer disease and mild cognitive impairment. Free Radic Biol Med 52:2292-301
Sultana, Rukhsana; Robinson, Renã A S; Di Domenico, Fabio et al. (2011) Proteomic identification of specifically carbonylated brain proteins in APP(NLh)/APP(NLh) × PS-1(P264L)/PS-1(P264L) human double mutant knock-in mice model of Alzheimer disease as a function of age. J Proteomics 74:2430-40
Chico, Laura K; Van Eldik, Linda J; Watterson, D Martin (2009) Targeting protein kinases in central nervous system disorders. Nat Rev Drug Discov 8:892-909
Lloyd, Eric; Somera-Molina, Kathleen; Van Eldik, Linda J et al. (2008) Suppression of acute proinflammatory cytokine and chemokine upregulation by post-injury administration of a novel small molecule improves long-term neurologic outcome in a mouse model of traumatic brain injury. J Neuroinflammation 5:28
Borders, Aaron S; de Almeida, Lucia; Van Eldik, Linda J et al. (2008) The p38alpha mitogen-activated protein kinase as a central nervous system drug discovery target. BMC Neurosci 9 Suppl 2:S12
Wing, Laura K; Behanna, Heather A; Van Eldik, Linda J et al. (2006) De novo and molecular target-independent discovery of orally bioavailable lead compounds for neurological disorders. Curr Alzheimer Res 3:205-14
Ralay Ranaivo, Hantamalala; Craft, Jeffrey M; Hu, Wenhui et al. (2006) Glia as a therapeutic target: selective suppression of human amyloid-beta-induced upregulation of brain proinflammatory cytokine production attenuates neurodegeneration. J Neurosci 26:662-70
Guo, Ling; LaDu, Mary Jo; Van Eldik, Linda J (2004) A dual role for apolipoprotein e in neuroinflammation: anti- and pro-inflammatory activity. J Mol Neurosci 23:205-12
Craft, Jeffrey M; Van Eldik, Linda J; Zasadzki, Magdalena et al. (2004) Aminopyridazines attenuate hippocampus-dependent behavioral deficits induced by human beta-amyloid in a murine model of neuroinflammation. J Mol Neurosci 24:115-22
Craft, Jeffrey M; Watterson, D Martin; Frautschy, Sally A et al. (2004) Aminopyridazines inhibit beta-amyloid-induced glial activation and neuronal damage in vivo. Neurobiol Aging 25:1283-92

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