Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Research Project (R01)
Project #
1R01AG013956-01
Application #
2055903
Study Section
Neurological Sciences Subcommittee 1 (NLS)
Project Start
1996-09-01
Project End
1999-08-31
Budget Start
1996-09-01
Budget End
1997-08-31
Support Year
1
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Washington University
Department
Neurology
Type
Schools of Medicine
DUNS #
062761671
City
Saint Louis
State
MO
Country
United States
Zip Code
63130
Han, Byung Hee; Zhou, Meng-Liang; Johnson, Andrew W et al. (2015) Contribution of reactive oxygen species to cerebral amyloid angiopathy, vasomotor dysfunction, and microhemorrhage in aged Tg2576 mice. Proc Natl Acad Sci U S A 112:E881-90
Kim, Jaekwang; Yoon, Hyejin; Horie, Takahiro et al. (2015) microRNA-33 Regulates ApoE Lipidation and Amyloid-? Metabolism in the Brain. J Neurosci 35:14717-26
Shin, Soomin; Walz, Katharine A; Archambault, Angela S et al. (2014) Apolipoprotein E mediation of neuro-inflammation in a murine model of multiple sclerosis. J Neuroimmunol 271:8-17
Dikranian, Krikor; Holtzman, David M (2014) The Ultrastructural Identity of Alzheimer's Pathology: Lessons from Animal Models. J Neurol Disord 2:e111
Esparza, Thomas J; Zhao, Hanzhi; Cirrito, John R et al. (2013) Amyloid-? oligomerization in Alzheimer dementia versus high-pathology controls. Ann Neurol 73:104-19
Verghese, Philip B; Castellano, Joseph M; Garai, Kanchan et al. (2013) ApoE influences amyloid-? (A?) clearance despite minimal apoE/A? association in physiological conditions. Proc Natl Acad Sci U S A 110:E1807-16
Dikranian, Krikor; Kim, Jungsu; Stewart, Floy R et al. (2012) Ultrastructural studies in APP/PS1 mice expressing human ApoE isoforms: implications for Alzheimer's disease. Int J Clin Exp Pathol 5:482-95
Basak, Jacob M; Kim, Jungsu; Pyatkivskyy, Yuriy et al. (2012) Measurement of apolipoprotein E and amyloid ? clearance rates in the mouse brain using bolus stable isotope labeling. Mol Neurodegener 7:14
Basak, Jacob M; Verghese, Philip B; Yoon, Hyejin et al. (2012) Low-density lipoprotein receptor represents an apolipoprotein E-independent pathway of A? uptake and degradation by astrocytes. J Biol Chem 287:13959-71
Wildsmith, Kristin R; Basak, Jacob M; Patterson, Bruce W et al. (2012) In vivo human apolipoprotein E isoform fractional turnover rates in the CNS. PLoS One 7:e38013

Showing the most recent 10 out of 93 publications