This application proposes to use data from the Longitudinal Study on Aging (LSOA) to assess the impact of physical activity and comorbid conditions on changes in functional status. Use of definitions of functional status encompassing both disability and dependency are proposed. Results from these analyses will allow a comparison of how physical activity and comorbid conditions may impact on disability and/or dependency, possibly leading to a better understanding of the role that physical activity may play in prolonging the time until functional decline and the need for long term care services. To achieve these aims, it will be necessary to develop statistical methods and computer programs permitting either marginal, transitional, subject-specific or latent variable modelling of discrete outcomes obtained from epidemiological surveys. Such methods must requisitely deal with issues such as: survey weights, stratified selection of clusters of participants, correlation of outcomes both within clusters and between repeated measurements on participants, and incomplete data resulting from institutionalization and death. The statistical methods resulting from this project will have broad applicability to other epidemiologic studies faced with any of the issues previously listed. An additional byproduct of this research project will be the availability of computer software useful for fitting the newly developed statistical methods.

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Research Project (R01)
Project #
5R01AG014131-04
Application #
6169428
Study Section
Special Emphasis Panel (ZRG4-EDC-2 (03))
Program Officer
Li, Rose M
Project Start
1997-09-30
Project End
2003-08-31
Budget Start
2000-09-01
Budget End
2003-08-31
Support Year
4
Fiscal Year
2000
Total Cost
$157,878
Indirect Cost
Name
Wake Forest University Health Sciences
Department
Public Health & Prev Medicine
Type
Schools of Medicine
DUNS #
937727907
City
Winston-Salem
State
NC
Country
United States
Zip Code
27157
Katula, Jeffrey A; Sipe, Marie; Rejeski, W Jack et al. (2006) Strength training in older adults: an empowering intervention. Med Sci Sports Exerc 38:106-11
Rejeski, W Jack; Ip, Edward H; Katula, Jeffrey A et al. (2006) Older adults' desire for physical competence. Med Sci Sports Exerc 38:100-5
Gallop, Robert J; Ten Have, Thomas R; Crits-Christoph, Paul (2006) A mixed effects Markov model for repeated binary outcomes with non-ignorable dropout. Stat Med 25:2398-426
Rejeski, W Jack; Brawley, Lawrence R (2006) Functional health: innovations in research on physical activity with older adults. Med Sci Sports Exerc 38:93-9
Focht, Brian C; Rejeski, W Jack; Ambrosius, Walter T et al. (2005) Exercise, self-efficacy, and mobility performance in overweight and obese older adults with knee osteoarthritis. Arthritis Rheum 53:659-65
Focht, Brian C; Gauvin, Lise; Rejeski, W Jack (2004) The contribution of daily experiences and acute exercise to fluctuations in daily feeling states among older, obese adults with knee osteoarthritis. J Behav Med 27:101-21
Focht, Brian C; Brawley, Lawrence R; Rejeski, W Jack et al. (2004) Group-mediated activity counseling and traditional exercise therapy programs: effects on health-related quality of life among older adults in cardiac rehabilitation. Ann Behav Med 28:52-61
Ratcliffe, Sarah J; Guo, Wensheng; Ten Have, Thomas R (2004) Joint modeling of longitudinal and survival data via a common frailty. Biometrics 60:892-9
Ten Have, Thomas R; Ratcliffe, Sarah J; Reboussin, Beth A et al. (2004) Deviations from the population-averaged versus cluster-specific relationship for clustered binary data. Stat Methods Med Res 13:3-16
Rejeski, W Jack; Brawley, Lawrence R; Ambrosius, Walter T et al. (2003) Older adults with chronic disease: benefits of group-mediated counseling in the promotion of physically active lifestyles. Health Psychol 22:414-23

Showing the most recent 10 out of 17 publications