Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Research Project (R01)
Project #
3R01AG014441-01S1
Application #
2640689
Study Section
Special Emphasis Panel (ZRG1-NLS-3 (01))
Project Start
1997-05-01
Project End
2002-04-30
Budget Start
1997-09-15
Budget End
1998-04-30
Support Year
1
Fiscal Year
1997
Total Cost
Indirect Cost
Name
University of Rochester
Department
Neurosciences
Type
Schools of Dentistry
DUNS #
208469486
City
Rochester
State
NY
Country
United States
Zip Code
14627
Coleman, Paul; Kurlan, Roger; Crook, Richard et al. (2004) A new presenilin Alzheimer's disease case confirms the helical alignment of pathogenic mutations in transmembrane domain 5. Neurosci Lett 364:139-40
Coleman, Paul D; Yao, Pamela J (2003) Synaptic slaughter in Alzheimer's disease. Neurobiol Aging 24:1023-7
Yao, Pamela J; O'Herron, Timothy M; Coleman, Paul D (2003) Immunohistochemical characterization of clathrin assembly protein AP180 and synaptophysin in human brain. Neurobiol Aging 24:173-8
Yao, Pamela J; Zhu, Min; Pyun, Eunice I et al. (2003) Defects in expression of genes related to synaptic vesicle trafficking in frontal cortex of Alzheimer's disease. Neurobiol Dis 12:97-109
Yao, Pamela J; Coleman, Paul D; Calkins, David J (2002) High-resolution localization of clathrin assembly protein AP180 in the presynaptic terminals of mammalian neurons. J Comp Neurol 447:152-62
Yao, P J; Weimer, J M; O'Herron, T M et al. (2000) Clathrin assembly protein AP-2 is detected in both neurons and glia, and its reduction is prominent in layer II of frontal cortex in Alzheimer's disease. Neurobiol Aging 21:921-9
Utal, A K; Coleman, P D (1999) Non-HPLC separation of water-soluble choline metabolites by two-dimensional high voltage electrophoresis and thin layer chromatography. J Neurosci Methods 90:13-21
Morsch, R; Simon, W; Coleman, P D (1999) Neurons may live for decades with neurofibrillary tangles. J Neuropathol Exp Neurol 58:188-97
Yao, P J; Morsch, R; Callahan, L M et al. (1999) Changes in synaptic expression of clathrin assembly protein AP180 in Alzheimer's disease analysed by immunohistochemistry. Neuroscience 94:389-94
Chow, N; Cox, C; Callahan, L M et al. (1998) Expression profiles of multiple genes in single neurons of Alzheimer's disease. Proc Natl Acad Sci U S A 95:9620-5

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