Age/Nutrition/Genes in Models of Psychiatirc Disorders

Gibson, Gary E.

Abstract

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Institute on Aging (NIA)
• Type: Research Project (R01)
• Project #: 5R01AG014600-06
• Application #: 2769426
• Study Section: Neuropharmacology and Neurochemistry Review Committee (NPNC)
• Project Start: 1992-06-01
• Project End: 2001-08-31
• Budget Start: 1998-09-01
• Budget End: 1999-08-31
• Support Year: 6
• Fiscal Year: 1998

Institution

• Name: Winifred Masterson Burke Med Research Institute
• DUNS #: 780676131
• City: White Plains
• State: NY
• Country: United States
• Zip Code: 10605

Publications

Gibson, Gary E; Hirsch, Joseph A; Fonzetti, Pasquale et al. (2016) Vitamin B1 (thiamine) and dementia. Ann N Y Acad Sci 1367:21-30

Huang, Hsueh-Meei; Chen, Huan-Lian; Gibson, Gary E (2014) Interactions of endoplasmic reticulum and mitochondria Ca(2+) stores with capacitative calcium entry. Metab Brain Dis 29:1083-93

Bubber, P; Hartounian, V; Gibson, G E et al. (2011) Abnormalities in the tricarboxylic acid (TCA) cycle in the brains of schizophrenia patients. Eur Neuropsychopharmacol 21:254-60

Gibson, Gary E; Starkov, Anatoly; Blass, John P et al. (2010) Cause and consequence: mitochondrial dysfunction initiates and propagates neuronal dysfunction, neuronal death and behavioral abnormalities in age-associated neurodegenerative diseases. Biochim Biophys Acta 1802:122-34

Huang, Hsueh-Meei; Chen, Huan-Lian; Gibson, Gary E (2010) Thiamine and oxidants interact to modify cellular calcium stores. Neurochem Res 35:2107-16

Karuppagounder, Saravanan S; Xu, Hui; Shi, Qingli et al. (2009) Thiamine deficiency induces oxidative stress and exacerbates the plaque pathology in Alzheimer's mouse model. Neurobiol Aging 30:1587-600

Shi, Qingli; Risa, Øystein; Sonnewald, Ursula et al. (2009) Mild reduction in the activity of the alpha-ketoglutarate dehydrogenase complex elevates GABA shunt and glycolysis. J Neurochem 109 Suppl 1:214-21

Karuppagounder, Saravanan S; Pinto, John T; Xu, Hui et al. (2009) Dietary supplementation with resveratrol reduces plaque pathology in a transgenic model of Alzheimer's disease. Neurochem Int 54:111-8

Gibson, Gary E; Karuppagounder, Saravanan S; Shi, Qingli (2008) Oxidant-induced changes in mitochondria and calcium dynamics in the pathophysiology of Alzheimer's disease. Ann N Y Acad Sci 1147:221-32

Karuppagounder, Saravanan S; Xu, Hui; Pechman, David et al. (2008) Translocation of amyloid precursor protein C-terminal fragment(s) to the nucleus precedes neuronal death due to thiamine deficiency-induced mild impairment of oxidative metabolism. Neurochem Res 33:1365-72