Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Research Project (R01)
Project #
1R01AG014744-01
Application #
2386019
Study Section
Special Emphasis Panel (ZRG1-NLS-3 (01))
Program Officer
Oliver, Eugene J
Project Start
1997-08-01
Project End
2000-07-31
Budget Start
1997-08-01
Budget End
1998-07-31
Support Year
1
Fiscal Year
1997
Total Cost
Indirect Cost
Name
Massachusetts General Hospital
Department
Type
DUNS #
City
Boston
State
MA
Country
United States
Zip Code
02199
Berezovska, O; Jack, C; Deng, A et al. (2001) Notch1 and amyloid precursor protein are competitive substrates for presenilin1-dependent gamma-secretase cleavage. J Biol Chem 276:30018-23
Jack, C; Berezovska, O; Wolfe, M S et al. (2001) Effect of PS1 deficiency and an APP gamma-secretase inhibitor on Notch1 signaling in primary mammalian neurons. Brain Res Mol Brain Res 87:166-74
Berezovska, O; Jack, C; McLean, P et al. (2000) Aspartate mutations in presenilin and gamma-secretase inhibitors both impair notch1 proteolysis and nuclear translocation with relative preservation of notch1 signaling. J Neurochem 75:583-93
Berezovska, O; Jack, C; McLean, P et al. (2000) Rapid Notch1 nuclear translocation after ligand binding depends on presenilin-associated gamma-secretase activity. Ann N Y Acad Sci 920:223-6
Liao, A; Gomez-Isla, T; Clatworthy, A et al. (1999) Lack of association of presenilin-1 intron-8 polymorphism with neuropathological features of Alzheimer's disease. Brain Res 816:295-8
Berezovska, O; Frosch, M; McLean, P et al. (1999) The Alzheimer-related gene presenilin 1 facilitates notch 1 in primary mammalian neurons. Brain Res Mol Brain Res 69:273-80
Berezovska, O; McLean, P; Knowles, R et al. (1999) Notch1 inhibits neurite outgrowth in postmitotic primary neurons. Neuroscience 93:433-9
Berezovska, O; Xia, M Q; Hyman, B T (1998) Notch is expressed in adult brain, is coexpressed with presenilin-1, and is altered in Alzheimer disease. J Neuropathol Exp Neurol 57:738-45
Xia, M Q; Berezovska, O; Kim, T W et al. (1998) Lack of specific association of presenilin 1 (PS-1) protein with plaques and tangles in Alzheimer's disease. J Neurol Sci 158:15-23