This application proposes to extend ongoing investigations in the Framingham Offspring Study which is examining biological and behavioral risk factors for bone loss and related fractures to include measures of serum osteocalcin (total and degree of carboxylation) and plasma vitamin K (phylloquinone) concentrations to assess the influence of vitamin K status on BMD. Plasma 25-hydroxyvitamin D also will be assayed to evaluate whether the relationship between vitamin K status and bone health is influenced by vitamin D status. These biochemical measurements will be compared to BMD measurements of the spine and hip collected at the 6th consecutive physical examination. From the Original Framingham Cohort of 3800 participants, 2000 males and females, ages 28-84 years will be studied. Covariates in addition to 25(OH) D concentrations include: age, anthropometric data, physical activity, medication use, smoking and diet including energy, protein, calcium, alcohol, and caffeine. The proposed studies will identify factors that lead to bone loss and help clarify the role of vitamin K status in the development of osteoporosis. Results of the studies proposed could lead to effective intervention programs that reduce bone loss resulting in a decreased risk and incidence of osteoporosis.

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Research Project (R01)
Project #
5R01AG014759-03
Application #
6168970
Study Section
Nutrition Study Section (NTN)
Program Officer
Sherman, Sherry
Project Start
1998-09-01
Project End
2002-07-31
Budget Start
2000-08-01
Budget End
2001-07-31
Support Year
3
Fiscal Year
2000
Total Cost
$324,919
Indirect Cost
Name
Tufts University
Department
Type
Schools of Medicine
DUNS #
604483045
City
Boston
State
MA
Country
United States
Zip Code
02111
Shea, M Kyla; Booth, Sarah L (2016) Concepts and Controversies in Evaluating Vitamin K Status in Population-Based Studies. Nutrients 8:
Hansen, J G; Gao, W; Dupuis, J et al. (2015) Association of 25-Hydroxyvitamin D status and genetic variation in the vitamin D metabolic pathway with FEV1 in the Framingham Heart Study. Respir Res 16:81
Rehder, Douglas S; Gundberg, Caren M; Booth, Sarah L et al. (2015) Gamma-carboxylation and fragmentation of osteocalcin in human serum defined by mass spectrometry. Mol Cell Proteomics 14:1546-55
Dashti, Hassan S; Shea, M Kyla; Smith, Caren E et al. (2014) Meta-analysis of genome-wide association studies for circulating phylloquinone concentrations. Am J Clin Nutr 100:1462-9
Shea, M Kyla; Booth, Sarah L; Miller, Michael E et al. (2013) Association between circulating vitamin K1 and coronary calcium progression in community-dwelling adults: the Multi-Ethnic Study of Atherosclerosis. Am J Clin Nutr 98:197-208
Booth, Sarah L; Centi, Amanda; Smith, Steven R et al. (2013) The role of osteocalcin in human glucose metabolism: marker or mediator? Nat Rev Endocrinol 9:43-55
Misra, Devyani; Booth, Sarah L; Tolstykh, Irina et al. (2013) Vitamin K deficiency is associated with incident knee osteoarthritis. Am J Med 126:243-8
O'Seaghdha, Conall M; Hwang, Shih-Jen; Holden, Rachel et al. (2012) Phylloquinone and vitamin D status: associations with incident chronic kidney disease in the Framingham Offspring cohort. Am J Nephrol 36:68-77
Ma, Jiantao; Ross, Alastair B; Shea, M Kyla et al. (2012) Plasma alkylresorcinols, biomarkers of whole-grain intake, are related to lower BMI in older adults. J Nutr 142:1859-64
Liu, E; McKeown, N M; Pittas, A G et al. (2012) Predicted 25-hydroxyvitamin D score and change in fasting plasma glucose in the Framingham offspring study. Eur J Clin Nutr 66:139-41

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