Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Research Project (R01)
Project #
5R01AG015239-08
Application #
6043100
Study Section
Neurology A Study Section (NEUA)
Project Start
1997-08-15
Project End
2000-07-31
Budget Start
1999-08-01
Budget End
2000-07-31
Support Year
8
Fiscal Year
1999
Total Cost
Indirect Cost
Name
University of Colorado Denver
Department
Dentistry
Type
Schools of Dentistry
DUNS #
065391526
City
Aurora
State
CO
Country
United States
Zip Code
80045
Zaman, Vandana; Boger, Heather A; Granholm, Ann-Charlotte et al. (2008) The nigrostriatal dopamine system of aging GFRalpha-1 heterozygous mice: neurochemistry, morphology and behavior. Eur J Neurosci 28:1557-68
Boger, Heather A; Middaugh, Lawrence D; Zaman, Vandana et al. (2008) Differential effects of the dopamine neurotoxin MPTP in animals with a partial deletion of the GDNF receptor, GFR alpha1, gene. Brain Res 1241:18-28
Willis, L; Quintero, E M; Nelson, M et al. (2005) Regulation of trophic factor expression by innervating target regions in intraocular double transplants. Cell Transplant 14:21-9
Quintero, E M; Willis, L M; Zaman, V et al. (2004) Glial cell line-derived neurotrophic factor is essential for neuronal survival in the locus coeruleus-hippocampal noradrenergic pathway. Neuroscience 124:137-46
Zaman, Vandana; Nelson, Matthew E; Gerhardt, Greg A et al. (2004) Neurodegenerative alterations in the nigrostriatal system of trkB hypomorphic mice. Exp Neurol 190:337-46
Zaman, V; Li, Z; Middaugh, L et al. (2003) The noradrenergic system of aged GDNF heterozygous mice. Cell Transplant 12:291-303
Helt, C E; Hoernig, G R; Albeck, D S et al. (2001) Neuroprotection of grafted neurons with a GDNF/caspase inhibitor cocktail. Exp Neurol 170:258-69
Granholm, A C; Helt, C; Srivastava, N et al. (2001) Effects of age and GDNF on noradrenergic innervation of the hippocampal formation: studies from intraocular grafts. Microsc Res Tech 54:298-308
Zuch, C L; Nordstroem, V K; Briedrick, L A et al. (2000) Time course of degenerative alterations in nigral dopaminergic neurons following a 6-hydroxydopamine lesion. J Comp Neurol 427:440-54
Granholm, A C; Reyland, M; Albeck, D et al. (2000) Glial cell line-derived neurotrophic factor is essential for postnatal survival of midbrain dopamine neurons. J Neurosci 20:3182-90

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