Mechanisms of amyloid-beta clearance.

Bacskai, Brian J.

Abstract

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Institute on Aging (NIA)
• Type: Research Project (R01)
• Project #: 5R01AG020570-02
• Application #: 6698814
• Study Section: Special Emphasis Panel (ZRG1-BDCN-3 (01))
• Program Officer: Snyder, Stephen D
• Project Start: 2003-02-01
• Project End: 2007-01-31
• Budget Start: 2004-02-01
• Budget End: 2005-01-31
• Support Year: 2
• Fiscal Year: 2004
• Total Cost: $287,613

Institution

• Name: Massachusetts General Hospital
• DUNS #: 073130411
• City: Boston
• State: MA
• Country: United States
• Zip Code: 02199

Publications

Garcia-Alloza, Monica; Borrelli, Laura A; Thyssen, Diana H et al. (2013) Four-dimensional microglia response to anti-A? treatment in APP/PS1xCX3CR1/GFP mice. Intravital 2:

Garcia-Alloza, Monica; Borrelli, Laura A; Hyman, Bradley T et al. (2010) Antioxidants have a rapid and long-lasting effect on neuritic abnormalities in APP:PS1 mice. Neurobiol Aging 31:2058-68

Coma, M; Sereno, L; Da Rocha-Souto, B et al. (2010) Triflusal reduces dense-core plaque load, associated axonal alterations and inflammatory changes, and rescues cognition in a transgenic mouse model of Alzheimer's disease. Neurobiol Dis 38:482-91

Garcia-Alloza, Monica; Ferrara, Brian J; Dodwell, Sarah A et al. (2007) A limited role for microglia in antibody mediated plaque clearance in APP mice. Neurobiol Dis 28:286-92

Garcia-Alloza, M; Borrelli, L A; Rozkalne, A et al. (2007) Curcumin labels amyloid pathology in vivo, disrupts existing plaques, and partially restores distorted neurites in an Alzheimer mouse model. J Neurochem 102:1095-104

Prada, Claudia M; Garcia-Alloza, Monica; Betensky, Rebecca A et al. (2007) Antibody-mediated clearance of amyloid-beta peptide from cerebral amyloid angiopathy revealed by quantitative in vivo imaging. J Neurosci 27:1973-80

Robbins, Elissa M; Betensky, Rebecca A; Domnitz, Sarah B et al. (2006) Kinetics of cerebral amyloid angiopathy progression in a transgenic mouse model of Alzheimer disease. J Neurosci 26:365-71

Guo, Shuzhen; Wang, Sophia; Kim, Woo Jean et al. (2006) Effects of apoE isoforms on beta-amyloid-induced matrix metalloproteinase-9 in rat astrocytes. Brain Res 1111:222-6

Garcia-Alloza, Monica; Dodwell, Sarah A; Meyer-Luehmann, Melanie et al. (2006) Plaque-derived oxidative stress mediates distorted neurite trajectories in the Alzheimer mouse model. J Neuropathol Exp Neurol 65:1082-9

Garcia-Alloza, Monica; Robbins, Elissa M; Zhang-Nunes, Sandy X et al. (2006) Characterization of amyloid deposition in the APPswe/PS1dE9 mouse model of Alzheimer disease. Neurobiol Dis 24:516-24