This research applies strategies of latent growth curve (LGC) modeling with a structural equation framework to examine intra-individual change in trajectories of cognitive performance in old age and its correlates, particularly age, education, health, and physical and sensory functioning. The proposed work focuses explicitly on the following objectives: to confirm patterns of decline with age across a broad spectrum of mental abilities using both crosssectional and longitudinal assessments of cognitive performance in nationally representative samples of the older population; to ascertain the extent to which cross-sectional age-differences in cognitive functioning are spuriously due to cohort-related factors, such as level of schooling, or other age-related phenomena, e.g., comorbidity and sensory functioning; to assess the age-related intra-individual trajectories of several measures of cognitive functioning as well as age-linked covariates such as comorbidity, other social and physical functioning, and sensory functioning using longitudinal data over periods of time of up to seven years; to assess the extent to which age-related declines in sensory impairment and health explain the link between aging and cognitive functioning in middle-aged and older adults, net of education and comorbidity; and to assess how patterns of cognitive decline and its covariates differ by sex and race/ethnicity in older adults. ? ? We investigate these issues using two innovative nationally-representative panel surveys of middle-aged and older adults: the original HRS (Health and Retirement Study) national panel study of preretirement men and women aged 51-61 assessed in 1992 (n=9,824) and reinterviewed in 1994, 1996, 1998 and 2000, and the parallel AHEAD (Study of Asset and Health Dynamics Among the Oldest Old) national panel study which interviewed adults aged 70 and above in 1993 (n=7,443) and reinterviewed in 1995, 1998 and 2000. The key elements of our design allow us to: (1) generalize to a national population of middle-aged and older individuals sampled using probability methods; (2) assess differences between birth cohorts in the processes studied; (3) assess occasion-based age changes in the population to estimate the nature and shape of intra-individual change; (4) assess inter-individual and inter-cohort differences in intra-individual change; (5) build synthetic cohort models of accelerated age-based change using the multiple cohort feature of the panel design; (6) assess the effects of fixed covariates and appropriately lagged timevarying covariates on individual differences in age-related change; and (7) assess the extent of bias in these aging functions introduced by problems of sample attrition and/or mortality.

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Research Project (R01)
Project #
5R01AG021203-03
Application #
6761731
Study Section
Special Emphasis Panel (ZRG1-RPHB-1 (01))
Program Officer
Elias, Jeffrey W
Project Start
2002-09-30
Project End
2006-07-31
Budget Start
2004-08-01
Budget End
2006-07-31
Support Year
3
Fiscal Year
2004
Total Cost
$255,909
Indirect Cost
Name
Pennsylvania State University
Department
Type
Organized Research Units
DUNS #
003403953
City
University Park
State
PA
Country
United States
Zip Code
16802