Research on the association between education and health has not been able to escape the criticism that factors other than education are responsible for this repeatedly observed, but potentially spurious, association. If the association between education and health is causal, the pathways through which education impact health remain to be fully elucidated. This application seeks to 1) obtain an estimate of the effect of education on multiple adult health outcomes independent of several determinants of both schooling and later adult health, and 2) evaluate the contribution of several potential pathways hypothesized to account for the association between education and health. This proposal is submitted by investigators from developmental and social epidemiology, medicine, health education and literacy, economics, psychology and biostatistics, and is based on adult follow-up studies of the New England cohorts of the National Collaborative Perinatal Project.
The first aim i s to conduct analyses of data recently obtained from a family study of 2,000 subjects who have been followed from birth through age 40; these analyses will incorporate a detailed measure of adult health status, prospective measures of social, familial, and individual determinants of education that were collected between 1959 and 1976, and a sibling design to account for potential unmeasured familial variables. In these analyses we will determine the 'adjusted' effects of education on the following health outcomes: diagnoses of cancer, cardiovascular disease, asthma and diabetes; self-rated health; and behavioral risk factors including current and lifetime indicators of tobacco use and substance abuse. We will also test the hypothesis that psychological processes (depression, anxiety, perceived social status, and perceived stress) mediate the association between education and health. The second and third aims of this study involve new data collection from 800 of these 2,000 subjects.
Aim two focuses on elucidating the causal effects of education on biological precursors of cardiovascular disease and diabetes.
The third aim will be to investigate the role of education in improving health through enhancement of functional literacy skills. The prospective nature of this study, the comprehensive assessment of parental and childhood variables, and the hypothesis-driven tests of causation and potential mechanisms make this project uniquely suited to evaluate the link between education and improved health outcomes.

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Research Project (R01)
Project #
5R01AG023397-02
Application #
6804425
Study Section
Special Emphasis Panel (ZRG1-SNEM-2 (50))
Program Officer
Chon-Lee, Angie J
Project Start
2003-09-30
Project End
2007-08-31
Budget Start
2004-09-01
Budget End
2005-08-31
Support Year
2
Fiscal Year
2004
Total Cost
$497,219
Indirect Cost
Name
Harvard University
Department
Social Sciences
Type
Schools of Public Health
DUNS #
149617367
City
Boston
State
MA
Country
United States
Zip Code
02115
Huang, Grace; Cherkerzian, Sara; Loucks, Eric B et al. (2018) Sex Differences in the Prenatal Programming of Adult Metabolic Syndrome by Maternal Androgens. J Clin Endocrinol Metab 103:3945-3953
Paradis, Angela D; Shenassa, Edmond D; Papandonatos, George D et al. (2017) Maternal smoking during pregnancy and offspring antisocial behaviour: findings from a longitudinal investigation of discordant siblings. J Epidemiol Community Health 71:889-896
Paradis, Angela D; Koenen, Karestan C; Fitzmaurice, Garrett M et al. (2016) Impact of persistent and adolescent-limited antisocial behaviour on adult health outcomes. J Epidemiol Community Health 70:1004-10
Non, Amy L; Román, Jorge Carlos; Gross, Christopher L et al. (2016) Early childhood social disadvantage is associated with poor health behaviours in adulthood. Ann Hum Biol 43:144-53
Paradis, Angela D; Fitzmaurice, Garrett M; Koenen, Karestan C et al. (2015) A prospective investigation of neurodevelopmental risk factors for adult antisocial behavior combining official arrest records and self-reports. J Psychiatr Res 68:363-70
Loucks, Eric B; Gilman, Stephen E; Howe, Chanelle J et al. (2015) Education and coronary heart disease risk: potential mechanisms such as literacy, perceived constraints, and depressive symptoms. Health Educ Behav 42:370-9
Stinson, Lynda J; Stroud, Laura R; Buka, Stephen L et al. (2015) Prospective evaluation of associations between prenatal cortisol and adulthood coronary heart disease risk: the New England family study. Psychosom Med 77:237-45
Slopen, Natalie; Loucks, Eric B; Appleton, Allison A et al. (2015) Early origins of inflammation: An examination of prenatal and childhood social adversity in a prospective cohort study. Psychoneuroendocrinology 51:403-13
Gilman, Stephen E; Loucks, Eric B (2014) Another casualty of sibling fixed-effects analysis of education and health: an informative null, or null information? Soc Sci Med 118:191-3
Appleton, Allison A; Loucks, Eric B; Buka, Stephen L et al. (2014) Divergent associations of antecedent- and response-focused emotion regulation strategies with midlife cardiovascular disease risk. Ann Behav Med 48:246-55

Showing the most recent 10 out of 31 publications