The Study of Osteoporotic Fractures (SOF) is a cohort of 10,366 women who were greater than or equal to 65 years old at enrollment in 1986-7. During 18 years and 8 examinations, SOF has developed a comprehensive array of phenotypic data, along with archives of 53,000 biological specimens and 67,500 radiographs. Findings from SOF, reported in 235 papers, have shaped clinical practice and guidelines for fracture prevention, and advanced the understanding of cognitive function, breast cancer, osteoarthritis, and other age-related conditions. SOF continues to be very productive, with 93 publications since our last renewal in 2000, including 60 articles from 45 external, and mostly junior, investigators. All SOF data are now available publicly via SOF Online. We propose to sustain, build, and produce important discoveries from these unique SOF resources. The SOF cohort has become one of the largest, longest, and best characterized cohorts of women in the 9th and 10th decades of life, the fastest growing segment of the US population. In addition to data about risk factors, bone mass, and fractures, we have nearly two decades of serial assessments of lower extremity function, cognitive function, and falls. In a Year 20 Exam, we will examine surviving SOF participants in clinic or home to expand our assessment of cognitive function with new dimensions and assess lower extremity function using the standardized and validated Short Physical Performance Battery. These examinations will allow us to analyze why some women have excellent cognitive function and lower extremity function so late in life. We will use blood stored from our Year 10 Exam to test the hypotheses that excellent renal function, low levels of inflammation, and normal levels of 25(OH)Vitamin D are associated with maintaining and achieving excellent lower extremity function, high cognitive function, a low risk of falls, and a low risk of hip fracture into the 9th and 10th decades of life. Potential public health impacts: While the oldest old women are the fastest growing segment of the US population, little is known about how to maintain their independence. Renal function, inflammation, and vitamin D levels are modifiable. If our hypotheses are born out, this may lead to trials and recommendations about lifestyle, vitamin D supplementation, or medication, to promote high levels of function late in life. ? ? ?

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Research Project (R01)
Project #
2R01AG027574-22A1
Application #
7147561
Study Section
Special Emphasis Panel (ZRG1-HOP-S (02))
Program Officer
Sherman, Sherry
Project Start
1986-02-01
Project End
2009-07-31
Budget Start
2006-09-01
Budget End
2007-07-31
Support Year
22
Fiscal Year
2006
Total Cost
$425,723
Indirect Cost
Name
Kaiser Foundation Research Institute
Department
Type
DUNS #
150829349
City
Oakland
State
CA
Country
United States
Zip Code
94612
Sun, Jianping; Oualkacha, Karim; Forgetta, Vincenzo et al. (2018) Exome-wide rare variant analyses of two bone mineral density phenotypes: the challenges of analyzing rare genetic variation. Sci Rep 8:220
Ward, Michael E; Gelfand, Jeffrey M; Lui, Li-Yung et al. (2018) Reduced contrast sensitivity among older women is associated with increased risk of cognitive impairment. Ann Neurol 83:730-738
Schousboe, John T; Kats, Allyson M; Langsetmo, Lisa et al. (2018) Associations of recent weight loss with health care costs and utilization among older women. PLoS One 13:e0191642
Diem, Susan J; Lui, Li-Yung; Langsetmo, Lisa et al. (2018) Effects of Mobility and Cognition on Maintenance of Independence and Survival Among Women in Late Life. J Gerontol A Biol Sci Med Sci 73:1251-1257
Leng, Yue; Stone, Katie; Ancoli-Israel, Sonia et al. (2018) Who Take Naps? Self-Reported and Objectively Measured Napping in Very Old Women. J Gerontol A Biol Sci Med Sci 73:374-379
Nelson, Heidi D; Lui, Lily; Ensrud, Kris et al. (2018) Associations of Smoking, Moderate Alcohol Use, and Function: A 20-Year Cohort Study of Older Women. Gerontol Geriatr Med 4:2333721418766127
Kassem, Ahmed M; Ganguli, Mary; Yaffe, Kristine et al. (2018) Anxiety symptoms and risk of dementia and mild cognitive impairment in the oldest old women. Aging Ment Health 22:474-482
Huang, Grace; Coviello, Andrea; LaValley, Michael P et al. (2018) Surgical Menopause and Frailty Risk in Community-Dwelling Older Women: Study of Osteoporotic Fractures. J Am Geriatr Soc 66:2172-2177
Woods, Gina N; Huang, Mei-Hua; Cawthon, Peggy M et al. (2018) Patterns of menopausal hormone therapy use and hyperkyphosis in older women. Menopause 25:738-743
Medina-Gomez, Carolina; Kemp, John P; Trajanoska, Katerina et al. (2018) Life-Course Genome-wide Association Study Meta-analysis of Total Body BMD and Assessment of Age-Specific Effects. Am J Hum Genet 102:88-102

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